Protein-Ligand Interactions: From Molecular Recognition to Drug Design (METHODS AND PRINCIPLES IN MEDICINAL CHEMISTRY)

Book Description

The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding.

Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed.

An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.

Customer Reviews:

Great book.......2003-11-18

This is a nice book, not so long, compact! with all the references needed for who is doing protein-structure based drug design!
Luca http://www.abo.fi/~lsettimo

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

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Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Manufacturer: Wiley-VCH
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Binding: Hardcover

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ASIN: 3527311513

Book Description

In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.

Adenovirus Methods and Protocols, Vol 2: Ad Proteins, RNA, Lifecycle, Host Interactions, and Phyologenetics (Methods in Molecular Medicine)

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Adenovirus Methods and Protocols, Vol 2: Ad Proteins, RNA, Lifecycle, Host Interactions, and Phyologenetics (Methods in Molecular Medicine)
William S.M., Ed. Wold
Manufacturer: Humana Press
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Binding: Hardcover

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Adenovirus Methods and Protocols, Vol 1: Adenovirus, Vectors, Quantitation, and Animal Models (Methods in Molecular Medicine)

ASIN: 1588299015

Book Description

Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding important chapters from the first edition, the authors have added new chapters that address innovative, exciting areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers in their respective areas of expertise.

Volume 1 addresses several important techniques for construction of adenoviruses for use as vectors and for basic research. Highlighted topics include deletion mutants, capsid modifications, insertions, and gene replacements in human, murine, bovine, and ovine adenoviruses. In Volume 2, the authors focus on methods that elucidate and quantitate the interactions of Ad with the host. Each of the protocols in these volumes provides a general introduction, followed by tried-and-true step-by-step methods. Both novice and experienced researchers will reap tremendous benefit from these groundbreaking volumes in Ad research.

Dna-protein Interactions: Principles and Protocols (METHODS IN MOLECULAR BIOLOGY (PAPERBACK/SPIRAL))

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Dna-protein Interactions: Principles and Protocols (METHODS IN MOLECULAR BIOLOGY (PAPERBACK/SPIRAL))
Tom Moss
Manufacturer: Humana Press
ProductGroup: Book
Binding: Plastic Comb

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ASIN: 0896036715

Book Description

Dr. Tom Moss assembles the new standard collection of cutting-edge techniques to identify key protein-DNA interactions and define their components, their manner of interaction, and their manner of function, both in the cell and in the test tube. The techniques span a wide range, from factor identification to atomic detail, and include multiple DNA footprinting analyses, including in vivo strategies, gel shift (EMSA) optimization, SELEX, surface plasmon resonance, site-specific DNA-protein crosslinking, and UV laser crosslinking. Comprehensive and broad ranging, DNA-Protein Interactions: Principles and Protocols, 2nd Edition, offers a stellar array of over 100 up-to-date and readily reproducible techniques that biochemists and molecular, cellular, and developmental biologists can use successfully today to understand DNA-protein interactions.

Protein-Protein Interactions: Methods and Protocols (Methods in Molecular Biology (Cloth))

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Protein-Protein Interactions: Methods and Protocols (Methods in Molecular Biology (Cloth))
Haian Fu
Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1588291200

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A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches, such as the Scansite program for computational analysis. These powerful tools are essential for deciphering how proteins interact with each other to form biological networks, as well as for unraveling protein-protein interactions in disease to find novel therapeutic targets.

Applications of Chimeric Genes and Hybrid Proteins, Part C: Protein-Protein Interactions and Genomics (Methods in Enzymology, Volume 328) (Methods in Enzymology)

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Applications of Chimeric Genes and Hybrid Proteins, Part C: Protein-Protein Interactions and Genomics (Methods in Enzymology, Volume 328) (Methods in Enzymology)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 012182229X

Book Description

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Rna Protein Interactions: A PRACTICAL APPROACH (Practical Approach Series (Cloth))

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Rna Protein Interactions: A PRACTICAL APPROACH (Practical Approach Series (Cloth))
CHRISTOPHER, ED. SMITH
Manufacturer: Oxford University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0199636508

Book Description

RNA-protein interactions play a vital role in gene transcription and protein expression. Interactions such as the synthesis of mRNA by RNA polymerases, to the essential modification of RNA by the proteins of the spliceosome complex, and the highly catalytic action of the ribosome in protein synthesis, are established as being fundamental to the function of RNA. Recent research into, for example, the role of RNA as a catalyst, has elucidated many more interactions with proteins that are vital to cell function. RNA - Protein Interactions: A Practical Approach provides a clear and comprehensive guide to the experimental procedures used in studying RNA - protein interactions. The approaches covered range from those initially used to detect a novel RNA-protein interaction, various biochemical and genetic approaches to purifying and cloning RNA binding proteins, through to methods for an in depth analysis of the structural basis of the interaction. The volume includes a number of procedures that have not previously been covered in this type of manual. These include the production of site-specifically modified RNAs by enzymatic and chemical methods and in vivo screening for novel RNA - protein interactions in yeast and E. coli . This is the first volume to gather in one place this wide array of approaches for studying RNA - protein interactions. As is customary for the Practical Approach series, the writing is characterized by a clear explanatory style with many detailed protocols. This informative book will be a valuable aid to laboratory workers in biochemistry and molecular biology - graduate students, postdoctoral and senior scientists - whose research encompasses this field.

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Nucleic Acid Structure and Recognition
Stephen Neidle
Manufacturer: Oxford University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 019850635X

Book Description

This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigation for nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acids) discussed. Also covered are the conformational features of nucleic acid building blocks, including a description of how base-pair morphologies are analysed; the structures of DNA double helices and helical oligonucleotides, emphasising current ideas on sequence-dependent structure; and DNA-DNA interactions, including triplexes and quadruplexes. The principles of RNA folding, ribosome, and ribozyme structure are also surveyed. Both covalent and non-covalent nucleic acid interactions with small molecules are described, with the emphasis on recognition principles and sequence specific gene recognition. The principles of protein - nucleic acid are covered, focussing on regulatory proteins. Nucleic Acid Structure and Recognition will therefore equip readers with a good understanding of all the important aspects of this major field. The Nucleic Acid Database (NDB) crystallographic and NMR structures for the nucleic acid structures described in the book are freely available through the Nucleic Acid Structure and Recognition website.

G Protein-coupled Receptors (Methods in Signal Transduction)

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Comprehensive membrane receptor methodology compendium

G Protein-coupled Receptors (Methods in Signal Transduction)
Tatsuya, Ed. Haga
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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G Protein-Coupled Receptors in Drug Discovery

ASIN: 0849333849

Book Description

Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors. This volume is useful at both the university and industrial levels, and is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation. Pharmacologists, neuroscientists, biochemists, industrial scientists and molecular biologists will find this book useful.

Customer Reviews:

Comprehensive membrane receptor methodology compendium.......2001-12-03

Comprehensive compendium from leading scientists in the field of membrane receptor function and methodology. Appealing material is presented by Dr. Birdsall on receptor-radioligand binding analysis and ligand-receptor allosteric interactions. Other highlights are the chapters covering heterologous receptor expression techniques, receptor-ion channel methodology and receptor-structure analysis. A must have for those interested in this field.

Protein-Lipid Interactions: New Approaches and Emerging Concepts (Springer Series in Biophysics)

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Protein-Lipid Interactions: New Approaches and Emerging Concepts (Springer Series in Biophysics)
Reyes C., Ed Mateo
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

ASIN: 3540284001

Book Description

Biological membranes have long been identified as key elements in a wide variety of cellular processes including cell defense communication, photosynthesis, signal transduction, and motility; thus they emerge as primary targets in both basic and applied research. This book brings together in a single volume the most recent views of experts in the area of proteinâ€“lipid interactions, providing an overview of the advances that have been achieved in the field in recent years, from very basic aspects to specialized technological applications. Topics include the application of X-ray and neutron diffraction, infrared and fluorescence spectroscopy, and high-resolution NMR to the understanding of the specific interactions between lipids and proteins within biological membranes, their structural relationships, and the implications for the biological functions that they mediate. Also covered in this volume are the insertion of proteins and peptides into the membrane and the concomitant formation of definite lipid domains within the membrane.

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