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The Geometry of Biological Time
Arthur T. Winfree Manufacturer: Springer ProductGroup: Book Binding: Hardcover Similar Items:
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ASIN: 0387989927 |
Book Description
From cell division to heartbeat, clocklike rhythms pervade the activities of every living organism. The cycles of life are ultimately biochemical in mechanism but many of the principles that dominate their orchestration are essentially mathematical.
The Geometry of Biological Time describes periodic processes in living systems and their non-living analogues in the abstract terms of nonlinear dynamics. Enphasis is given in phase singularities, waves, and mutual synchronization in tissues composed of many clocklike units. Also provided are descriptions of the best-studied experimental systems such as chemical oscillators, pacemaker neurons, circadian clocks, and excitable media organized into biochemical and bioelectrical wave patterns in two and three dimensions. No theoretical background is assumed; the required notions are introduced through an extensive collection of pictures and easily understood examples. This extensively updated new edition incorporates the fruits of two decades' further exploration guided by the same principles. Limit cycle theories of circadian clocks are now applied to human jet lag and are understood in terms of the molecular genetics of their recently discovered mechanisms. Supercomputers reveal the unforeseen architecture and dynamics of three-dimensional scroll waves in excitable media. Their role in life-threatening electrical aberrations of the heartbeat is exposed by laboratory experiments and corroborated in the clinic. These developments trace back to three basic mathematical ideas.
Customer Reviews:
A classic.......2007-06-09
Completely Interdisciplinary Science.......2001-08-19
The book has two main parts: a first half containing ten chapters mostly about principles and theory, and a second half containing thirteen more about specific experimental systems. It seems curiously hard to decide whether the subject matter is narrow to the point of caricaturing academic specialization, or incredibly broad to the point of suggesting a smorgasbord for science dilettantes. Among the forty thousand academic science journals viable today, not one is devoted to the topic of "biological waves, oscillations, and phase singularities" featured in this book, so it must be too narrow even for such tastes. Yet the literature drawn upon spans an unmatchably wide gamut, ranging from practical medicine to abstract topology, from recent molecular genetics to history of science, from 1836 to 2000. And Science Citations Index shows that the first edition has been cited about a thousand times in widely diverse publications, continuing at about constant rate over the past twenty years. Maybe this is why Springer-Verlag chose to provoke a 2nd edition even after so long.
Updating is usually an opportunity to erase blunders, but this author instead preserves and draws attention to them: how did this mistake happen, and how did the item come to be seen from a different perspective, with different meaning? To avoid giving offense the author preserves mostly his own blunders for such object lessons while going out of his way to credit the innovations of others.
Almost the whole 1980 text is preserved, with new material intercalated on a shaded background, except for two entirely new fat chapters. One concerns the self-organization of excitable media into three-dimensional vortices with exotic topologies. This is almost wholly theoretical (supercomputer calculations and topology): the only ones discovered in the laboratory (so far) are simple vortex rings. The website mentioned in the preface contains much of the same material but more beautifully illustrated in subsequent Powerpoint lectures not mentioned in the book. The other new chapter concerns real cardiology and the role of phase singularities in sudden cardiac death. This seems a morass of details where I would have preferred to see the elegant tree that grew from seeds planted in the first edition. This tree was recognized midway between editions by a medical award normally given only to cardiologists. The new chapter gives the impression that it is already being cut down or at least pruned, and the author is more concerned about the details of that process than about defending its original structure. His 1987 book, was written a few years before the anticipated role of phase singularities and rotors in cardiology found confirmation in quantitative experiments, so the interested reader (if any) must still resort to the cited journal literature for that story.
Another chapter reports on revolutionary developments entirely unforeseen in the first edition: this is the story of molecular genetics of the circadian biological clock. The author provides a readable summary of discoveries up to the end of 1999, but quite a lot of facts have accumulated since that time. The author's point of view is that present-day facts, while unanticipated in detail, do bear out the almost-forgotten theory elaborated in a 1963 book (Goodwin) as to basic principles, and the contrarian expectation stressed in the first edition, that the details may prove to be surprisingly diverse taxonomically.
One of the best resources this eight hundred page book provides is its dual index, with almost two thousand topics and as many cited references, half of them since the first edition. Because the material is both mathematical and experimental, and each item is encountered several times but from different directions in the text, the index is indispensable to persons with finite lifetime who accordingly prefer not to read every word in sequence. Find the topic, jot down its several pages, read one and note a reference from which that argument draws its data, then see the other index for all pages on which that source document is alluded to. The references, by the way, seem exceptionally complete and up-to-date (up to the last day of the 20th century, when it appears the ms was sent to press).
The preface points to a website for Errata. While this may be helpful to specialists, for the rest of us a better discovery lurks nearby: a link to a series of richly illustrated lectures given since the book went to press. These cover much of the same material in about three hundred substantially distinct slides but with entirely different organization in Powerpoint color (in contrast to about as many B&W line drawings in the book). The web site URL changed: it now seems to be eebweb.biosci.Arizona.edu/~art for Errata, and for the Powerpoints, eeb8.biosci.Arizona.edu/art/2000_lectures.
The author was professor of biological sciences at Purdue University until a few years after the first edition, and has since been professor of ecology and evolutionary biology at the University of Arizona. These seem peculiar credentials for authorship of a monograph mostly about topology, physical chemistry, and cardiac electrophysiology in an Applied Mathematics series. The key to understanding this phenomenon may be the first word, standing out in yellow against the green book cover: Interdisciplinary. Whatever may be hyped to the contrary, the academic world resents and resists activities that transgress its historically-defined disciplinary boundaries. You will find them all transgressed in this book.
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Fodor's Around Rome with Kids, 1st Edition: 68 Great Things to Do Together (Around the City with Kids)
Fodor's Manufacturer: Fodor's ProductGroup: Book Binding: Paperback Similar Items:
ASIN: 0676901883 Release Date: 2002-04-02 |
Book Description
Each book focuses on 68 terrific ideas for family days, from museums and puppet theaters to skyscrapers and parks. Written by parents who live in the cities they cover, these books are smart about what kids like--and about what parents need. All the details for planning are included: addresses, phone numbers, admission prices, and age-appropriateness. "Hey, Kids!" info boxes provide fun facts and interesting trivia about the destination, and "Kid-Friendly Eats" features recommend three or four places to grab a bite to eat nearby. Fun to read and easy to use, these handy little guides make it easy to plan an enjoyable, hassle-free day with children in the world's most popular cities. They're perfect idea books for every city parent and grandparent, and indispensable aids for families on vacation.Customer Reviews:
fodor's around rome with kids.......2005-09-21
Could be a LOT more user-friendly if..........2005-08-12
Don't waste your money on this guide.......2004-03-29
Excellent resource for kid-friendly activities in Rome.......2003-11-22
Useful Info But Not Particularly Appealing for Kids.......2002-10-31
The organizaton of the book, counting down from 68, didn't make much sense. Is #68 the most interesting or #1? The red type is hard on the eyes. The little "Hey Kids" call outs indicated that this is really a book for adults to use to guide their kids.
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The Oxford Picture Dictionary: English-Brazilian Portugese Edition (Oxford Picture Dictionary Program)
Norma Shapiro , and Jayme Adelson-Goldstein Manufacturer: Oxford University Press, USA ProductGroup: Book Binding: Paperback Similar Items:
ASIN: 0194362817 |
Book Description
A comprehensive, flexible, and up-to-date vocabulary reference and teaching tool for English language learning. The Oxford Picture Dictionary and its components create a highly teachable programme that can be used as a complete, four-skills beginning course, or as a language development supplement and practical reference. h4span style="font-size: smaller; color: #ff0000"NEW /span Grammar Activity Book/h4Customer Reviews:
Excelent Dictionary.......2007-09-22
The Oxford Pictionary: English-Brazilian Portuguese Edition.......2007-08-10
Dictionary?.......2007-06-26
Easy learning!.......2007-03-15
Excellent to get vocabulary.......2003-08-01
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Floral Designs and Motifs for Artists, Needleworkers and Craftspeople (Dover Pictorial Archive Series)
Charlene Tarbox Manufacturer: Dover Publications ProductGroup: Book Binding: Paperback Similar Items:
ASIN: 0486247163 |
Book Description
Customer Reviews:
Floral Designs and Motifs for Artists, Needleworkers and Craftspeople.......2007-05-14
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1001 Floral Motifs and Ornaments for Artists and Craftspeople (Dover Pictorial Archive Series)
Carol Belanger Grafton Manufacturer: Dover Publications ProductGroup: Book Binding: Paperback Similar Items:
ASIN: 048625352X |
Book Description
Customer Reviews:
It is what it is!.......2007-01-15
Useless to me........2001-12-02
Not of use to me........1998-11-23
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Decorative Floral Designs and Motifs CD-ROM and Book (Dover Electronic Clip Art)
Madeleine Orban-Szontagh Manufacturer: Dover Publications ProductGroup: Book Binding: Paperback Similar Items:
ASIN: 0486995941 |
Book Description
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Floral Patterns (Asian Art Motifs from Korea, No 2)
Manufacturer: Ahn Graphics ProductGroup: Book Binding: Hardcover ASIN: 8970590013 |
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Art Is Flowering: Floral Motifs in Jewellery and Contemporary Art
Cornelie Holzach Manufacturer: Arnoldsche Verlagsanstalt GMBH ProductGroup: Book Binding: Hardcover ASIN: 389790277X |
Book Description
A sumptuously illustrated interdisciplinary book on flowers that - far from kitsch and cliche - makes the historical and contemporary cultural significance of bloom and blossom a treat for the senses.
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Flowers into Art: Floral Motifs in European Painting and Decorative Arts
Manufacturer: Univ of Washington Pr ProductGroup: Book Binding: Paperback ASIN: 9061791405 |
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Sunflowers (The Design Motifs Series)
Lindsay Porter Manufacturer: Lorenz Books ProductGroup: Book Binding: Hardcover ASIN: 1859671446 |
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