Book Description
Still brief - but with the chapters that you wanted - Steven Chapra’s new second edition is written for engineers and scientists who want to learn numerical problem solving. This text focuses on problem-solving (applications) rather than theory, using MATLAB, and is intended for Numerical Methods users; hence theory is included only to inform key concepts. The new second edition feature new material such as Numerical Differentiation and ODE's: Boundary-Value Problems.
Average customer rating:
- A Legit review from a REAL: reader
- Terrific Book
- Useful and Timely
- Recommended Book
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Structural Bioinformatics (Methods of Biochemical Analysis, V. 44)
Philip E. Ed. Bourne
Manufacturer: John Wiley & Sons
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Introduction To Protien Architecture
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Bioinformatics: Sequence and Genome Analysis
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ASIN: 0471201995 |
Book Description
From the Foreword
"[A] must read for all of us committed to understanding the interplay of structure and function...[T]he individual chapters outline the suite of major basic life science questions such as the status of efforts to predict protein structure and how proteins carry out cellular functions, and also the applied life science questions such as how structural bioinformatics can improve health care through accelerating drug discovery."
This book provides a basic understanding of the theories, associated algorithms, resources, and tools used in structural bioinformatics. The reader emerges with the ability to make effective use of protein, DNA, RNA, carbohydrate, and complex structures to better understand biological function. Moreover, it draws a clear connection between structural studies and the rational design of new therapies.
Customer Reviews:
A Legit review from a REAL: reader.......2006-06-16
Ok, there are 3 reviews listed here from what seems to be the authors or their closest friends... I give these about as much credit as whale dung at the bottom of the ocean. That being said, this *IS* an awesome summation of current knowledge in the fields of Structural biology and bioinformatics, especially for one with a working (undergraduate) knowledge of biological building blocks.
A few things of note: the book is aimed at biologists. This is not to imply that computer scientists or actuarial scientists will never understand this book, but rather implies that the approach to instruction is taken from the biological realm and then expanded to other related fields.
Also note that this is aimed strictly at comparative structural bioinformatics. While mentioned in the book, topics like transcription factors, x-ray crystalographic methods, or multi-cell signalling networks are best left for other books. This particular book, while touching on the subjects, does not go into much depth in these subjects. Personally, I feel this is all the better, allowing for a better primer of the subjects.
All in all, I have to say that this is one of the best books to date for an upper-undergraduate / graduate student to gain a working knowledge of Structural Bioinformatics. As such, I gladly rate this a 5 star book!
Terrific Book.......2003-10-17
"...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue." (Briefings in Bioinformatics)
Useful and Timely.......2003-09-03
"...a useful and timely summary of a rapidly expanding field." (Nature Structural Biology, Vol. 10, No. 8, August 2003)
Recommended Book.......2003-07-25
"...recommended for anyone who wishes to develop bioinformatics tools for protein structure analysis." (The Biotech Journal, April/May 2003)
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Microbial Proteomics: Functional Biology of Whole Organisms (Methods of Biochemical Analysis)
Ian Humphrey-Smith
Manufacturer: John Wiley and Sons
ProductGroup: Book
Binding: Hardcover
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ASIN: 0471699756 |
Book Description
Discover important lessons learned about whole organism biology via microbial proteomics
This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization.
Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include:
- Microbial pathogenesis at the proteome level
- Whole cell modeling
- Structural proteomics and computational analysis
- Biomolecular interactions
- Physiological proteomics
- Metabolic reconstruction using proteomics data
While presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed.
Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science.
Book Description
Vital information for discovering and optimizing new drugs
"Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors."
-Paul S. Anderson, PhD
This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications.
Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address:
* What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism?
* How are inhibitors evaluated for potency, selectivity, and mode of action?
* What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo?
* What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization?
Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted.
This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.
Download Description
The goal of this book is to provide chemists and pharmacologists with the key information they need to answer questions such as: What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? How are inhibitors properly evaluated for potency, selectivity, and mode of action? What are the potential advantages and liabilities of specific inhibition modalities with respect to efficacy in vivo? And finally, what information should medicinal chemists and pharmacologist expect from their biochemistry/enzymology colleagues in order to most effectively pursue lead optimization?
Customer Reviews:
Enzyme Kinetics.......2007-03-02
I have found this book very useful. If you have to use enzyme kinetics, and analyze the data, then you really should have this book. That it is recommended by Prof Cornish-Bowden attests to its accuracy.
Personally I find this topic difficult, but this book is well written, and I have a much better understanding of kinetics after getting this book.
Drug developers need this book.......2006-03-10
Books and reviews on drug design are often disappointing, but Evaluation of Enzyme Inhibitors in Drug Discovery is excellent; it is a book that should be on the shelves of anyone involved in rational drug development, and available to anyone interested in understanding how successful drugs work. It starts by explaining why enzymes are appropriate targets for a drug design in the first place, and goes on to emphasize that inhibiting an enzyme and producing the intended effect on the whole organism is not a trivial matter. As the author remarks, "dogmatic arguments that lead to a priori predictions of what will work best in a biological context more often than not reflect an incomplete understanding".
If rational drug design is ever to become a reality it will involve knowledge of much more than three-dimensional structure, though this sometimes seems to be the only aspect considered. It requires, of course, knowledge of the different kinds of inhibition and how the inhibitor affects enzyme activity at different concentrations of substrates and products. In addition, it requires some knowledge of the metabolic context in which the inhibited enzyme is embedded: if it has almost no flux control then inhibiting it -- even to a high degree -- may have almost no effect on the flux through it (though it may still have large effects on the metabolite concentrations around it). finally it requires understanding of what makes some molecules "drug-like", and others not: it is no use identifying a superb inhibitor of the ideal enzyme if there is no way of delivering it to the target. Copeland deals with all of these points, and others, in an appropriately elementary way. Apart from giving much more information about inhibition than he did in Enzymes (Wiley-Interscience, 2000), here he takes a more leisurely pace and the book should not offer any serious difficulty to anyone wanting to master the subject.
As the author explains, there is much more to enzyme inhibition than just competitive inhibition: some successful drugs are indeed competitive inhibitors, Methotrexate and Viagra among them, but others are not; Finasteride, for example, used for treating benign hypertrophy of the prostate, is an uncompetitive inhibitor of steroid 5alpha-reductase. Classifying inhibitors thus needs more than crude measures of IC50 values, and if these are used at all they need to be used in conjunction with knowledge of how they relate to inhibition constants.
Analysis of the kind set out in the book is essential for understanding why enzyme inhibitors work as drugs, but the sceptical reader may wonder how much of it is post hoc rationalization, and how much was actually used for discovering the drugs. Let us consider the 26 enzyme inhibitors that have become successful drugs that are listed in Chapter 1, from Acetazolamide, an inhibitor of carbonic anhydrase used to treat glaucoma, to Viagra, an inhibitor of phosphodiesterase that is now familiar to everyone. Modern Drug Discovery claimed in 1998 that "Viagra was discovered using a rational drug design approach", but was it? It was not originally conceived as a drug for treating erectile dysfunction, and its usefulness for this discovered almost by chance when it was noticed that some men who participated in clinical trials as a treatment for angina pectoris reported unexpected effects. Even as an inhibitor for phosphodiesterase, Viagra was found by making variations on the structure of Zaprinast, a weak inhibitor that had failed to become a useful anti-allergy treatment. There is little in this history to suggest rational drug design.
There are many good points about this book, but it is often difficult to find them, because the index is very poor. For example, there is a discussion of the characteristics of "drug-like" molecules (Lipinski's rules, etc.), but don't expect to learn this from the index; the only way to find it is to leaf through the pages. Fortunately it comes early in the book, but there are other equally important and equally secret topics later on. In other respects this is a fine achievement, a book that can be enthusiastically recommended.
Average customer rating:
- Fantastic! A must in any environmental scientist's library
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Handbook of Chemical Property Estimation Methods: Environmental Behavior of Organic Compounds
Warren J. Lyman ,
David H. Rosenblatt , and
William J. Reehl
Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover
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ASIN: 0841217610 |
Book Description
This handbook presents simple estimation methods for 26 important properties of organic chemicals that are of environmental concern. A must-have resource, this book facilitates the study of problematic chemicals in such applications as chemical fate modeling, chemical process design, and experimental design. Using the handbook's step-by-step instructions and a hand calculator, you'll be able to quickly and easily obtain the needed estimations. Environmental chemists, environmental managers, chemical engineers, pharmacologists, and other scientists will find this volume invaluable in assessing potential environmental problems relating to organic chemicals.
Customer Reviews:
Fantastic! A must in any environmental scientist's library.......1998-06-21
Gives a detailed explanation of the different properties needed for environmental modeling and even for chemical engineering design. Very well written, thought a little boring (is imposible to be funny with this kind of material). Puts you in the right track immediatly.
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Physical Chemistry for the Biological Sciences (Methods of Biochemical Analysis)
Gordon G. Hammes
Manufacturer: John Wiley & Sons
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Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding
ASIN: 0470122021 |
Book Description
Gain a practical, working knowledge of the physical chemistry essential for the biological sciences
Physical Chemistry for the Biological Sciences is an excellent resource for biochemistry and biology/health science professionals and students who need a basic understanding of thermodynamics, kinetics, hydrodynamics of macromolecules, and spectroscopy in order to explore molecular structure and chemical reactions. Approachable, yet thorough, the book presents physical chemistry in conceptual terms with a minimum of mathematics. Providing the basic knowledge and tools that every biologist should have to understand the quantitative interpretation of biological phenomena, it covers:
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Fundamentals of thermodynamics and chemical kinetics
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Fundamentals of spectroscopy and structure determination
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Ligand binding to macromolecules, hydrodynamics, and mass spectrometry
All techniques and concepts are clearly illustrated with relevant applications and examples from the biological sciences. Problems at the end of each chapter reinforce the principles. This is a succinct reference for practitioners, including bioorganic chemists, medicinal chemists, biochemists, pharmaceutical chemists, biologists, and professionals in fields such as pharmaceuticals, agriculture, and biotechnology. It's also an excellent textbook for graduate and upper-level undergraduate students in biochemistry, biology, and related fields.
Book Description
This book serves as both a text and a "how to" book, and contains several chapters detailing fundamental and applied aspects of Nanomedicine. There is also a separate section on "Experiments In Nanoscience and Nanotechnology" to help professors design experiments for graduate and undergraduate classes.
Textbook of Nanomedicine will be of paramount importance to teachers, students and scientists in academics and industry who practice Nanomedicine for training or for production of new generation of Nanomedicine-based diagnostic and therapeutic products. The textbook highlights all aspects related to the chemistry, physics and biology of nanoparticles including: size relationship of nanoparticles with biological cells, coupled with diagnostic/therapeutic properties of specific nanoparticles and the availability of sophisticated targeting vectors to target nanoparticles onto tumor cells/tumor tissue, potential applications to other diseases, and the applied implications of nanoscience and nanotechnology to dramatically increase our ability to detect and treat cancer and other diseases in the earliest stages.
Customer Reviews:
mass transfer in solution.......1999-08-08
mass transfer in solution, chemical reaction engineering and Fluid Mechanics.
Product Description
One of the primary references on analytical methods in soil science, Part 2 of the Methods series will be useful to all biogeoscientists, especially those with an interest in microbiology or bioremediation.
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HPLC of Peptides and Proteins: Methods and Protocols (Methods in Molecular Biology (Cloth))
Marie-Isabel, Ed. Aguilar
Manufacturer: Humana Press
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ASIN: 0896039773 |
Book Description
Hands-on experts from academia and industry comprehensively describe how to successfully perform all the critical HPLC techniques needed for the analysis of peptides and proteins. The methods range from commonly used techniques to those for capillary to large-scale preparative isolation. The authors have also presented a number of specific applications as case studies to illustrate the analytical approaches to a particular separation or assay challenge, with examples drawn from contemporary fields in biochemistry and biotechnology.
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