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Peroxisome Proliferators: Unique Inducers of Drug-Metabolizing Enzymes (Handbooks in Pharmacology and Toxicology)
David E. Moody
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover
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ASIN: 0849383056 |
Book Description
Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial, and regulatory areas of pharmacology and toxicology. This monograph, for the first time, has brought together researchers who deal specifically with drug-metabolizing enzymes and peroxisome proliferators. It contains an up-to-date review of peroxisome proliferation, with detailed tables on the 100 known peroxisome proliferators and studies on their hepatocarcinogic capacity. It provides current material from 12 different laboratories doing cutting-edge research on the effect of peroxisome proliferators on drug-metabolizing enzymes.The book covers the response of cytochrome P450s, UDP-glucuronosyltransferases, epoxide hydrolases, glutathione S-transferase, DT-diaphorase, and other enzymes.
Book Description
LA TIMES BEST SELLER! Day Hikes Around Los Angeles includes 82 hikes in and around a 50-mile radius of the city. Now in its fourth edition, this hiking guide has made the LA Times Bestseller list. Outdoor people living in the city will find the book essential. This
comprehensive guide provides access to the green areas in the metropolitan area, including coastal walks, mountain climbs, and solitary retreats in addition to well-known sites, such as a hike that treks up to the ¿HOLLYWOOD¿ sign.
Despite the imminent presence of the Los Angeles metropolis, there are thousands of acres of natural, undeveloped land with miles of hiking trails, from the coast to the interior mountains and valleys. Day Hikes Around Los Angeles includes a cross-section of scenery, ecosystems, and difficulty levels. Highlights include sweeping views from the ocean to
the city, magnificent rock formations, waterfalls, bluffs, ridge walks, weather-sculpted canyons, old ranch roads, architectural ruins, filming locations, large state parks, and cool shady retreats. All hikes can be completed during the day (although map sources and references are included for extending hikes).
Each hike includes a detailed map, accurate driving and hiking directions, and a quick overview of distance/time/elevation. Larger overall maps show the hike locations in the greater metropolitan area. The summaries allow the hiker to choose a trail appropriate to their
ability and desire.
Companion hiking guides, also in the Day Hike Books series, include Day Hikes Around Ventura County, Day Hikes Around Santa Barbara, and Day Hikes On the California Central Coast.
Customer Reviews:
Not bad, but some serious issues.......2007-02-19
I haven't gone on all 82 hikes in this book. But I have gone on a few, and on some the directions are not quite right. So if you get this book, here's some notes:
Hike 51: Rustic Canyon
This hike is awesome. However, if you go, go with someone who has gone before, or you WILL get lost. The trail in the canyon is not maintained whatsoever, and has pretty much disappeared at the tail end. The best way out is to slog through the stream, so you will be soaked. Be prepared.
Hike 66: Brush Canyon
It says to reach Mt Bell, to take a right on Mount Hollywood Drive. It's a left. The turnoff isn't far, but it's to the left. If you go right, the first turnoff takes you up to Mt Hollywood (a back way to Hike 68).
Many, many hikes:
Be very careful - there are numerous hikes where North is not at the top of the map. On some hikes, North is the bottom of the map. Who does that? If you don't realize this, you're going to get lost. Be sure to double check.
Other than that, some great hiking routes. Many are pretty far from "Los Angeles" - so be prepared for a bit of a drive sometimes. Also, there are NO hikes east of the 5 freeway - even though there are some fantasic hikes above Pasadena, Altadena, Azusa. Even a few above Whittier. They're just not in here at all. The majority of the hikes are nearer to the Ventura County Line than they are to Los Angeles. They're just not in here at all.
Mt. Lee and the Hollywood sign - Hike 64.......2007-02-19
I purchased this book for directions to hike to the Hollywood sign with a friend, and was not disappointed. The directions in this book take you as close as you can legally get to the sign. The map, driving directions, and hiking directions were quite accurate. The trailhead has been moved since this edition was published, but there were signs clearly directing us to and marking the new trailhead. The only unclear element was the listed hiking time, which the book says is 1.5 hours, not stating whether this is one-way or round-trip. Taking time along the trail to stop for water breaks on a warm sunny day and photograph the excellent vistas, it took us about 3 hours round-trip to complete the hike. I suppose if one did the hike in a hurry it might be completed in the stated time, but if you plan to admire the scenery, you should probably add at least an hour onto the hiking times provided in this book. Though there were several other groups of hikers on the trail with us (one group also using this book as a guide), there were many points where it was so quiet that you couldn't hear anything but nature sounds. Even the freeways and fellow hikers elsewhere along the trail were often inaudible. The views along the trail and from the top of Mt. Lee were gorgeous - we could see all the way to the ocean!
Super fun book.......2006-04-25
Considering that there are like 20 million people living in the LA area, it's sad no one's really written a review of this gem of a book. I find that even though people may have lived here their whole lives, they really haven't seen much of the city.
So what better way to get acquainted with my new home than this book? More interesting to me than "how to go to Disneyland with 110,000 other people" or "learning where the Orange Crush is located," is a book about some offbeat, and beautiful, parts of LA.
Case in point was the hike to Point Fermin I took Sunday. A fine day with my father-in-law, son, and daughter. My panama hat did yeoman's duty, and we enjoyed the wonderful scenery and relative solitude. The best part is, it didn't cost a dime. We even drove over the only suspension bridge in LA county to get there. My boss has lived in LA for forty years, and hadn't heard of this location.
Anyway, this book falls under the heading of "potentially life-changing books" not because the hikes are all that mind-blowing, but because it is the key to unlock experiences you'd otherwise never have. It's that little push that gives you permission to do something a little unusual, a little less safe, than your ordinary weekend. The exploration of such a complex city rich in natural beauty is a great gift, and opening the book is the first step on that journey.
Sean Penn says that now that men aren't hunters anymore, the only thing left for them is violence. I say that's not true. There's a whole world out there to explore, and a man can still try to see it for himself, and take pleasure in showing it to his family.
Book Description
Your one-stop guide to writing and selling books for children
Get the tools you need to:
- Develop story ideas that work
- Strengthen your writing skills
- Improve your work habits
- Write for different age groups
- Look at your work critically
- Submit proposals and manuscripts
- Find the right publisher for your work
- Understand and negotiate contracts
- Work with agents and editors
- Join the writing community
Do you dream of becoming the next J. K. Rowling? Are you excited about writing for children but have no idea how to begin or where to send your material? Now, respected children's writer Barbara Seuling gives you the essential steps to getting published in the competitive, exciting world of children's literature.
From finding story ideas and creating character sketches to plotting, writing dialogue, editing, and revising your work, you'll learn how to complete a manuscript and prepare it for submission. Whether you want to write picture or chapter books, fiction or nonfiction, poetry or plays, Seuling helps you master the different genres and capture a child's interest and imagination, from the early years to young adult. Her fully revised guide also covers the major developments in book publishing, including vital information about using the Internet to research the market and contact publishers. Seuling even discusses recent successes such as the Harry Potter series, as well as the growth of Amazon.com.
Complete with updated lists of writing organizations, marketing information, and recommended reading, this is the only guide you need to start writing, get published, and touch the lives of children.
Download Description
A fully revised and updated guide to success in the children¿s book market
Here, from a successful writer and editor of children¿s books, is the ultimate guide for aspiring authors who dream of publishing for children. Using her own experience as well as studies of recent successes like the Harry Potter series, Seuling outlines five steps to success: researching the marketplace, developing story ideas, strengthening writing skills and work habits, submitting proposals and manuscripts, and joining the writing community. With tips on how to use today¿s tools like e-mail and the Internet for contacting publishers and researching work, she offers a sensible approach that puts publication within reach of hopeful writers everywhere.
Barbara Seuling (New York, NY) has written and illustrated more than fifty children¿s books, including the popular Freaky Facts series. She is the founder and director of the Manuscript Workshop in Vermont.
Customer Reviews:
Good Reading.......2006-08-28
This book is easy to read and lots of information for the beginning writer or those who are contemplating being a writer.
Would definitely recommend it!
NEVER RECEIVED IT! (I rated one star because it won't let me rate it 0).......2006-06-02
I received an email on March 18, 2006, asking me to write a review. I've waited this long because I kept thinking I would receive it any day - It's June 1st and I still have not received this book!! I've called about it, and was told they would look into it (that was 1st part of May) - still nothing. Can someone tell me what's going on please!! Thank you (I think)?
Recommended reading if you want to get serious about writing!.......2005-09-11
I would definately recommend this book if you are serious about writing for children. Very useful, easy to understand and it covers all the ins and outs of the basics for writing for children and other negotiations etc.
Barbara Seuling Is Very Knowledgeable and Practical: I Know.......2004-06-15
Barbara Seuling was my instructor when I took a two-year writing course in writing children's literature from The Institute of Children's Literature. Ms. Seuling is exceedingly knowledgeable, skillful, talented, and very practical about writing children's literature and getting it published. Also, she writes instructions that are very easy to understand. I highly recommend this book.
Good place to start, BUT..........2004-03-24
Good place to start even theough this information changes rapidly. I'd still like to see a book on using self-publish companies like XLibris or Heliographica.com which more and more writers are using to create children's books.
Amazon.com
Though bits and pieces are somewhat outdated ("backspace 10 characters for right-hand margin," a chapter on getting published recommends), this is a fine and quite British introduction to the art of writing and illustrating children's books. Nine writers, illustrators, editors, librarians, and educators present a chapter or two each on such subjects as storytelling, classic children's fiction, contemporary themes in children's literature, illustration, and production. The format doesn't allow much of a chance for any one aspect of the business of children's books to be explored deeply, but the authors' strong affinity for children and their literature will help any potential children's-book creator adopt the right frame of mind for the work. Authors of children's books, says Gabrielle Maunder, must not underestimate the intelligence of their readers. And illustrators, says Catherine Storr, should do more than simply add pictures to the text; "the illustrator all writers long to meet," she says, "is the one who can take the text and, without radically changing it ... enormously enrich it." Most important, agree all the contributors here, is the need for authors and illustrators alike to understand the mind of the child. Getting published and sold is one thing, says illustrator (and writer) Celia Berridge; but true success "is knowing that your book really works for children." --Jane Steinberg
Customer Reviews:
Nice book.......2006-07-18
Good book for those wishing to know more about the field or not knowing where to start. When you get serious, you'll want to read some additional books on working with the publishing world. From what I've understood, very few agents will touch children's books. So, you'll likely be going it alone up until you really get established, if you do. That means you will be working directly with the publisher/editor yourself. As a result, you will need more information under your belt about the publishing world than what this book contains, but this is an excellent source to learn about everything else. It does include some starter info about the publishing end of things.
Very useful information.......2004-05-20
I found this book to be very useful as a source for writing better children's books. It includes specific style and writing techniques with examples to teach us to make a more powerful manuscript. I wish there were more books like this with even more ideas!
Good Start for Illustrators.......2003-09-14
Treld Pelkey Bicknell's 'How to Write and Illustrate Children's Books' is really more for illustrators of children's books then the writer's aspect of the book. It's a good source for that particular purpose. If you want a more indepth instruction on the children's book writing process I suggest Barbara Seuling's 'How to Write a Children's Book and Get It Published.' Bicknell's book is valuable for it's comprehensive topics and illustrations. The first part include topics of constructing a story from beginning to end (planning and plotting, story structure, dialogue). There's a section on getting to know your reader and choosing the right words. Plus other informative information like looking into the world of children and the influence of new writing. The second part is devoted to illustration and discusses getting to know your audience, the types of picture books (board, pop-ups, zig-zag, flap, half-flap, holes, pictorial consequences, long text, minimal text, wordless, picture strips). It combines pictures with interpeting a text and using your imagination. Building the porfolio follows in the creation process. The last part is devoted to getting published. Starting from making the book, preparing the roughs, the right style for the right job. The author tops it off with factual writing and researching, Fad & Novelty books and finding the right publisher. To find what's in the market I also suggest the 'Children's Book Writer and Illustrator's Market Book' as a directory in that field to find the right genre of which publisher to contact. This book is a handy source like the other two I mentioned.
Helpful to illustrators.......2001-08-18
As a published children's book author and illustrator, I found this book to be one of the more helpful guides for those interested in children's illustration. Most books in the "How to Write Children's Books" genre focus on the writer's perspective and neglect the illustrator. This book, with contributions by an Art Director, also addresses portfolio presentation, picture book layout, style, dummies, tearsheets and roughs. True, the book is somewhat dated and there are more comprehensive books on children's book publishing. However, I would highly recommend this book to fellow illustrators.
Book Description
This is a hip how-to handbook on writing and publishing for aspiring young writers. In a fun, informative style, the authors show kids how to practice and improve their writing, get published, and maybe even become famous in the process. The book contains practical advice and cool insights from real kid authors. Writer wannabes will learn: · how to begin a career in writing · ways to explore the genres of poetry, journalism, fiction, and nonfiction · where to find inspiration for stories · how to approach publishers and get published · how to improve writing through creative exercises Also included are profiles of ten young authors whose real-life successes send the message that getting one's work published is indeed possible.
Customer Reviews:
WOAH!.......2003-07-03
Was someone spying on me my whole life?? This book seemed to be written just for me (aren't I special). It has tips on how to overcome writer's block, how to make realistic and loveable charachters, building seamless plots, and even includes stories of young writers who made it big.
This book has been very helpful and I would recommend it to anyone who has hopes of writing and maybe publishing a great book someday.
An Awesome book to start on!.......2003-01-13
When I first borrowed this book from the library, I thought, Hey, It Looks OK. I'll Borrow It. I read the book that night and WOW! There's thing's you should know about your writing spot, a quiz to help start you in a good genre, personally for you, and even real stories about young writers you've made it. This is such a good book to buy or at least read and take notes off of.
An invaluable resource on how to begin!.......2001-10-18
In So You Wanna Be A Writer?, freelance writer and editor Vicki Hambleton and classroom teacher Cathleen Greenwood effectively collaborate to provide a superbly presented "how to" guide for young aspiring writers on how to practice and improve their writing and get what they write published! Young writers are shown how to begin a career in writing; explore different areas of writing (poetry, journalism, fiction, nonfiction); find creative ideas for improving their writing; and a wealth of practical advice for approaching publishers and getting published. So You Wanna Be A Writer? is enhanced with a current and extensive list of magazines, websites, contests, and book publishers actively soliciting "kid authors". There are illuminating profiles of ten "kid authors" who are already accomplishing their literary dreams by writing and getting attention for their work and thereby serve as illustrative examples for others. Whether a young author is writing to make money, advance a cause, or just for fun, So, You Wanna Be A Writer? is a strongly recommended and invaluable resource on how to begin!
Customer Reviews:
Wonderful advice!.......2002-12-15
This book is packed full of solid, good-sense advice for anyone interested in writing for children. The author uses clear examples and includes samples in many cases. Besides being well-written, it is easy to read and understand. Just follow her suggestions step-by-step and you'll see how you can improve your writing, even if you're already a published author.
Book Description
North Carolina is home to the only continuing pottery tradition in the United States outside the Native American tradition of the Southwest. Noted for this rich tradition from Seagrove to Pisgah, work produced here has earned the attention of collectors, artists, and visitors from around the globe. The collection of The Mint Museums in Charlotte, numbering more than 1,600 pieces, is considered the most comprehensive in any public institution. This volume catalogs more than four hundred individual pieces in the Museums' collection and includes five essays by authorities in the field of ceramics, providing a visual and textual guide to a vibrant living tradition.
Illustrated with hundreds of color photographs, the catalog includes descriptive entries on potters and potteries and details about individual pieces. These include traditional utilitarian wares from the eighteenth and nineteenth centuries, transitional or "fancy wares" made during the first half of the twentieth century, and contemporary objects. Displaying works from the four major pottery-producing areas of the state--Moravian settlements, Seagrove, the Catawba Valley, and the mountains--the collection tells the entire story of the North Carolina pottery tradition. Essays by collector and patron Daisy Wade Bridges, scholar Charles G. Zug III, gallery director Charlotte V. Brown, potter Mark Hewitt, and curator Barbara Stone Perry survey the history and significance of one of the state's best-known art forms.
Customer Reviews:
EXCELLENT INFORMATION WITH COLORED PICTURES.......2005-08-31
THIS BOOK IS A "MUST HAVE" FOR COLLECTORS OF NORTH CAROLINA POTTERY. THE TEXT IS FULL OF "MARKS OR SIGNATURES" OF THE POTTERS AND THEIR HISTORY. THE PICTURES SHOW THE GLAZES IN "TRUE COLOR" FOR EASY IDENTIFICATION.
A great treasure.......2004-12-01
If you have the slightest interest in North Carolina's unique pottery tradition, this book provides a lavishly illustrated catalog of the collection of the Mint Museums of Charlotte, NC. Each potter's biography, genealogy and work history is included with an example of the work of each. There are essays by pottery experts to explain the background on various types of pottery, techniques, locations, etc., as well as the history of pottery making in North Carolina. This would make a wonderful Christmas gift for any North Carolinian.
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