Dynamics of the Bacterial Chromosome: Structure and Function

Book Description

This book provides an unique overview on bacterial genetics, bacterial genome projects and gene technology and its applications in biological and biomedical research and medicine.

Book Description

This book is an account of some of the most malignant infectious microbes encountered by humans and the genetic disorders they spawned. It's also a tale of how scientific progress over the past 150 years is giving man the tools to fight back.

Bacterial Genomes and Infectious Diseases

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Bacterial Genomes and Infectious Diseases
Voon L., Ed. Chan
Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 158829496X

Book Description

The emergence and reemergence of infectious diseases, an increasing rate of antibiotic-resistant variants of pathogens, and the threat of bioterrorism underscore the importance of bacterial genomes and infectious diseases. Bacterial Genomes and Infectious Diseases presents major findings about bacterial genomes and their impact on strategy and approach for investigating mechanisms of pathogenesis of infectious diseases. This book imparts fundamental knowledge on the structure, organization, and evolution of bacterial genomes. The value and power of comparative genomics and proteomics, bioinformatics, microarrays, and knockout animal models in analyzing genomes, bacteria-host interactions and disease are demonstrated. Also discussed are the genomes of virulent and nonvirulent strains and species, origin and evolution of pathogens, different models of bacteria-host interactions, and diseases mechanisms.

On the forefront of critical research, Bacterial Genomes and Infectious Diseases provides valuable reading for infectious disease specialists, medical microbiologists, clinician scientists, and undergraduate and graduate students in microbiology, pathobiology, and genetics.

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Bacterial Genomes
FRANS J. DE BRUIJN
Manufacturer: Chapman & Hall
ProductGroup: Book
Binding: Hardcover

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ASIN: 0412991411

Book Description

A wide range of microbiologists, molecular biologists, and molecular evolutionary biologists will find this new volume of singular interest. It summarizes the present knowledge about the structure and stability of microbial genomes, and reviews the techniques used to analyze and fingerprint them. Maps of approximately thirty important microbes, along with articles on the construction and relevant features of the maps are included. The volume is not intended as a complete compendium of all information on microbial genomes, but rather focuses on approaches, methods and good examples of the analysis of small genomes.

The Dynamic Bacterial Genome (Advances in Molecular and Cellular Microbiology)

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The Dynamic Bacterial Genome (Advances in Molecular and Cellular Microbiology)

Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Hardcover

Genetics | Evolution | Science | Subjects | Books

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ASIN: 0521821576

Book Description

This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Genome rearrangements are a result of the actions of discrete genetic elements such as conjugative transposons, plasmids, phage, and non conjugative transposons. Bacteria also contain systems to mediate genetic rearrangements such as the general recombination pathway and specialized endogenous recombination mechanisms. The biological effects of these rearrangements are far-reaching and impact on bacterial virulence, antibiotic resistance and the ability of bacteria to avoid the attentions of the host immune system (e.g. antigenic variation). These rearrangements also provide the raw material on which natural selection can act. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. This book is written by leading research workers and will be an invaluable resource for graduate students and researchers in this field.

Exploring Parasite Genomes (Parasitology)

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Exploring Parasite Genomes (Parasitology)
David, Ed. Rollinson
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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Book Description

Information on parasite genomes will be fundamental to the future directions of parasitology research. Complete parasite gene sequence data, currently available for some pathogenic bacteria, will provide essential biological information and clues to novel drug and vaccine targets. The papers in this volume summarize the current state of various parasite genome projects and the bioinformatics of parasite genome analysis. This book covers such topics as pathogenic bacteria, yeasts, trypanosomes and apicomplexan parasites, schistosomes, and nematode pathogens of both humans and plants. The generation and handling of parasite genome data will significantly enhance the understanding of basic parasite biology and will offer novel opportunities to control parasitic diseases in humans, animals, and plants.

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Gene Expression-1. Bacterial Genomes
Benjamin Lewin
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Paperback
ASIN: B000NUOT0E

Genome Management in Prokaryotes (Biotechnology By Open Learning)

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Genome Management in Prokaryotes (Biotechnology By Open Learning)
BIOTOL , B C Currell , and R C E Dam-Mieras
Manufacturer: Butterworth-Heinemann
ProductGroup: Book
Binding: Paperback

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Book Description

Provides a thorough understanding of the key features and properties of the genetic exchange systems that occur in prokaryotic cells and explains how genes in these systems are expressed and regulated. It also provides a range of techniques used in
microbial genetics. Particular emphasis is placed on gene structure and the regulation of prokaryotic genes. The role of bacteriophages as mediators of genetic exchange is also discussed.

Genomes and Genomics of Nitrogen-fixing Organisms (Nitrogen Fixation: Origins, Applications, and Research Progress)

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Genomes and Genomics of Nitrogen-fixing Organisms (Nitrogen Fixation: Origins, Applications, and Research Progress)
Rafael, Ed. Palacios
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 1402030533

Book Description

This book is the self-contained third volume of a comprehensive series on nitrogen fixation. It presents the state-of-the-art in regards to genomic sciences applied to nitrogen-fixation research. The advent of genomic sciences represents a new era for biology. The classic paradigm based on the gene has now changed to a paradigm that is based on the genome. The knowledge of the complete nucleotide sequence of a genome and its consequences with regard to both transcription and translation lead to an integral and comprehensive view of the biochemistry and physiology of an organism. Moreover, comparative genomic studies provide new insights for a better understanding of the evolutionary process. Nitrogen-fixation research has fully entered the genomics era since the first complete nucleotide sequences of a rhizobial symbiotic plasmid and a methanogenic archaeon were first reported in 1997. Now, the complete nucleotide sequences of many genomes of nitrogen-fixing organism from different taxonomic groups are available. This volume includes chapters devoted to the genomes of specific organisms as well as chapters that cross organismal lines and analyse general aspects centred on functional genomics, genome dynamics, taxonomy, and evolution. No other available work provides the up-to-date and in-depth coverage of this volume, which is intended to serve as an indispensable reference work for academic, governmental, and industrial scientists working in the areas of genomics, transcriptomics, and proteomics, including those studying evolution and taxonomy; to assist students to enter this challenging area of research; and to provide science administrators with ready access to vital relevant information.

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Microbial Genomes (Infectious Disease)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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Pathogenomics: Genome Analysis of Pathogenic Microbes

ASIN: 1588291898

Book Description

This collection of diverse articles by the pioneers of modern genomics takes stock of the current state of the field and elucidates the contribution that sequencing genomes has made to our understanding of microbial metabolism and evolution. Through twenty-eight thought-provoking chapters, the authors describe some of the most common computational methods and their applications to studying pathogenic microorganisms, show how genomics can be used to reconstruct the history and dynamism of the microbial world, and discuss issues as diverse as reconstruction of metabolic pathways, cell cycle processes, microbial evolution, metagenomics, and vaccine development. Additional chapters deal with microarrays and expression analysis and the role of genomic in drug discovery.

Customer Reviews:

Very informative.......2006-09-22

Having gone through the preparation to climb Kili, I found this book to be very informative ... especially the sections on traveling through Tanzania and Kenya. Much thanks to the other reviewers for warnings on the use of Diamox and the need for conditioning.

An essential guide!.......2005-08-02

Cameron Burns has filled a void with the publication of this climbing and trekking guide for Kilimanjaro and Mount Kenya. While much is probably written about Kili, there is very little practical literature about Mount Kenya. The introductory pages are full of useful hints for traveling in Kenya that, from my recent experience there, all ring true. The route descriptions on Mount Kenya, while lacking in some detail, certainly convey the necessary information for a successful climb. It is already time for a new edition, however, since some of the features have changed. Kami Camp, for instance, no longer exists.

Agree with Keith Kendall - Caution advised.......2002-01-31

As others have noted Mr. Burn's book is well written, and informative. But as Keith D. Kendall correctly observes in a review elsewhere on this page, the notion that a trek to the summit of a 19,000 foot peak may be accomplished without achieving a high level of cardiovascular fitness is not only misleading and potentially dangerous, but frankly absurd. Ditto for Mr. Burn's comments on the use of Diamox, which he either doesn't understand (his comments in the book indicate little experience with its correct use), or again, dismisses out of hand as he has never had to use it. You may. The information in the book is valuable, but as with everything else, it is only a single point of view. I liked the book a great deal, but take some pause when obvious misinformation is attributed to an `expert' source.

Good preplanner.......2001-08-12

This is a good book to read before you actually book a trip. There is alot of information in this book that puts you in a frame of reference of where you are going. Africa is a total different world from the United States so it is nice to know what you are getting into. In regards to some of the info I think Burns thinks that everyone is in as great a shape as he is in. I would recommend overtraining and doing altitude to make the trip as enjoyable as possible. I was in great shape and zipped up to the top but anyone can make it if they go slow. Also don't worry about travelers checks they take any kind. I would recommend booking an African travel agent and advoid using an American agent. This will save you money. We used Easy Travel and Tours for our Tanzania trip and were very satisfied with them

Be careful of a strong bias on the part of the author.......2000-05-24

Mr. Burns book was informative but I took strong exception to his reccomendations on physical preperation for the trip. Further, his reccomendation on nonuse of Diamox for altitude sickness prevention also disturbed me. Mr. Burns gives the impression that the trek is nothing more that a brisk walk and that a genuine workout program of cardiovascular training and weight training is of little use. If one were to rest on his reccomendations they would stand a very small chance of reaching the summit. Further, the use of Diamox for many who summited proved to be a key factor in their success. If one were to take these sections of his book to heart I do not think their Kilimanjaro experience would be a positive one. Be in the best condition you are able and have Diamox at the ready if you need it.

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Irritating, pedantic, but instructive

Loved it!

A Fun Way to Learn 'When, Where, Why, How, Who.'

Fun romp through the thornier parts of grammar

How to Write More Books.

How Not to Write: The Essential Misrules of Grammar
William Safire
Manufacturer: W. W. Norton & Company
ProductGroup: Book
Binding: Paperback

Grammar | Words & Language | Reference | Subjects | Books
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The Right Word in the Right Place at the Right Time: Wit and Wisdom from the Popular Language Column in the New York Times Magazine

Words of Wisdom

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The Grammar Bible: Everything You Always Wanted to Know About Grammar but Didn't Know Whom to Ask

ASIN: 039332723X

Book Description

These fifty humorous misrules of grammar will open the eyes of writers of all levels to fine style.

How Not to Write is a wickedly witty book about grammar, usage, and style. William Safire, the author of the New York Times Magazine column "On Language," homes in on the "essential misrules of grammar," those mistakes that call attention to the major rules and regulations of writing. He tells you the correct way to write and then tells you when it is all right to break the rules. In this lighthearted guide, he chooses the most common and perplexing concerns of writers new and old. Each mini-chapter starts by stating a misrule like "Don't use Capital letters without good REASON." Safire then follows up with solid and entertaining advice on language, grammar, and life. He covers a vast territory from capitalization, split infinitives (it turns out you can split one if done meaningfully), run-on sentences, and semi-colons to contractions, the double negative, dangling participles, and even onomatopoeia. Originally published under the title Fumblerules

Customer Reviews:

Irritating, pedantic, but instructive.......2006-08-12

Relevant cliché: learn the rules, then break them.

If you can spare one to two hours, give this book a try. There are worse ways to spend that time.

I would not recommmend sticking to every "rule", though. I would have given this book two stars had it not been for, the at-times, creative and, at-times, funny ways the author presented his "essential misrules".

Having said the above, I have not come across a better book than William Zinsser's "On Writing Well" in this league.

Loved it!.......2006-06-05

This is a real jewel and I liked it better than Lynn Truss's book on grammar. It was funny, insightful and I learned several important things.

Safire has a masterful command of the English language, is concise and direct, and writes in a style that almost anyone can understand.

The only part that left me confused was when to use "if I was" and "if I were." I'm still not sure exactly what the difference is between those two and must confess that I'm one of those sloppy writers who uses "if I were" indiscriminately!

Great read and very humorous. Highly recommended. Sentence fragments notwithstanding, I found a great deal of important info in this book.

Sigrid Macdonald
Author and Editor

A Fun Way to Learn 'When, Where, Why, How, Who.'.......2006-01-18

This instruction guide to good writing was entertaining, as meant to be, but not exactly up-to-date on today's styles. Words have changed; styles of writing have changed; people have changed. Grammar has been my 'thing' since high school and I still tend to write in the old-fashioned way using which instead of that, and I notice that older people who are educated do the same thing.

Outdated slang is as foreign to me as Latin, as I have never been into slang, nor have I tried the pedagogical technique. It appears that he had a similar rule book about fifteen years ago, so perhaps this is a bit outdated. He gives the most common mistakes of writers. What about the most common mistakes in grammar when speaking? If people write the way they talk, we really would need an instruction booklet for reference.

Each of the fifty sections used a 'misrule' (sort of a moral of the story for grammar): A Do Not Do This concerning capitals, contractions, prepositions, dangling participles, sentence fragments, double negatives, split infinitives, and onomatopoeia (zap!). My English professor husband used to love to throw that word at me, as he did 'inimitably' Safire didn't mention misspellings. He did go on about colloquialisms, cliches and euphemisms but that's way in the past.

He tells his correct way to write and when it's okay to break his rules. We have a 'grammar expert' who does a short column in the Sunday newspaper who worked as a law clerk. How, I'd like to know, does that make him a grammar guru? He was never an English teacher, and I don't agree with his rule that you can never use enough, or too many, 'thats' -- he's wrong, so I quit looking at his stuff. Only uneducated people use 'that' when they could substitute something clearer like 'who' for people. People are not supposed to be 'thats.' But, that's my pet peeve. He reminds us that it takes a complete thought (noun and verb) to make a sentence; the noun can be omitted when the subject is implied.

A good rule of thumb is to write succinctly and in language which anyone can understand. If you use the big words you might find only in a dictionary, no one will listen, or read your work. I'm sure he has a good column on language in the New York paper, but I have not seen it. I did, however, enjoy playing around with this little book. Grammar can be fun!

Fun romp through the thornier parts of grammar.......2005-11-27

William Safire, of course, is a master of the English language. In "How Not To Write," Safire attempts in a humorous way to lead the reader through the thornier thickets of grammar. To a large extent he succeeds, demonstrating proper and improper grammar throug humorous example.

A worthwhile addition to the library of anyone who writes. The only problem I see is trying to remember all the rules when you really need them . . . like when you're writing.

Jerry

How to Write More Books........2005-10-08

First-rate little book filled with erudition, wit and deep respect for good writing. The author knows how to make every word and punctuation mark count. Highly recommend to anyone who cares about writing. This book, HOW NOT TO WRITE, is, however, a re-issue of Mr. Safire's 1990 book FUMBLERULES. Both are equally good, because they are the same book. I purchased Fumblerules used here on Amazon for a tiny price. Buy the new one here, too. You'll be glad to have either version.

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This is a "Must Have" addition to your DNA library...

Excellent contribution in a new subject of growing importance

Trace Your Roots with DNA

DNA and Genealogy

Genes

Trace Your Roots with DNA: Using Genetic Tests to Explore Your Family Tree
Megan Smolenyak , and Ann Turner
Manufacturer: Amazon Remainders Account
ProductGroup: Book
Binding: Paperback
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ASIN: B000GYI1TW

Book Description

Written by two of the country's top genealogists, this authoritative book is the first to explain how new and groundbreaking genetic testing can help you research your ancestryAccording to American Demographics, 113 million Americans have begun to trace their roots, making genealogy the second most popular hobby in the country (after gardening). Enthusiasts clamor for new information from dozens of subscription-based websites, email newsletters, and magazines devoted to the subject. For these eager roots-seekers looking to take their searches to the next level, DNA testing is the answer. After a brief introduction to genealogy and genetics fundamentals, the authors explain the types of available testing, what kind of information the tests can provide, how to interpret the results, and how the tests work (it doesn't involve digging up your dead relatives). It's in expensive, easy to do, and the results are accurate: It's as simple as swabbing the inside of your cheek and popping a sample in the mail.Family lore has it that a branch of our family emigrated to Argentina and now I've found some people there with our name. Can testing tell us whether we're from the same family?My mother was adopted and doesn't know her ethnicity. Are there any tests available to help her learn about her heritage? I just discovered someone else with my highly unusual surname. How can we find out if we have a common ancestor? These are just a few of the types of genealogical scenarios readers can pursue. The authors reveal exactly what is possible-and what is not possible-with genetic testing. They include case studies of both famous historial mysteries and examples of ordinary folks whose exploration of genetic genealogy has enabled them to trace their roots.

Customer Reviews:

This is a "Must Have" addition to your DNA library..........2007-09-03

As a DNA-surname research group administrator, I tend to buy every book, VHS, or DVD I can find regarding the use of DNA research in support of traditional genealogy.

Of the 12-15 books I have purchased so far, Megan Smolenyak's touchstone reference work continues to be the one I reach for when I have a question myself.

Easily read and understood, this book makes complex concepts readily accessible with clear illustrations, definitions, real-world examples, and authoritative references when needed. I am not naturally science-minded, but as a good researcher, I want to be able to use every tool in the box. This is my go-to book for that purpose.

Buy as many DNA books and tapes as you want, but your DNA library will not be complete without this classic introduction to the concepts involved in genetic genealogy.

I highly recommend it!

CHT in Virginia

Excellent contribution in a new subject of growing importance.......2007-06-08

Even a decade ago, "genetic genealogy" barely existed as an almost science-fictional idea. Now, it's one of the most debated topics in our field and thousands of family researchers are involved in projects to identify ancestors through DNA analysis. (I'm in two projects now, myself.) It's a rather complicated subject, though, and for those (like me) who barely scraped through high school biology, the more books for beginners, the better. Smolenyak is a well-known genealogist and lead researcher for the PBS Ancestors series and Turner has become one of the principal popularizers of genetic genealogy on the Internet. The important point is that both have been pursuing family research since the days of manual typewriters and paper library catalogs, and that's the perspective from which they approach the discussion. They explain very clearly why DNA analysis can tell you only who your ancestors *aren't*, not necessarily who they *are*, and the strategic differences between researching your father's and your mother's lineage. They lay out the options and limitations among uncovering ethnic origins (what about that Indian great-grandmother?), global origins (Eastern European? or Scandinavian?), "deep maternal" ancestry (the "daughters of Eve" thing), and even African tribal origins. How do you set up a family or surname research project, attract participants, ensure their trust, and analyze and publish the results? And what do all those numbers in the lab report mean? This is very much a practical book and I strongly recommend it, perhaps in conjunction with Thomas H. Shawker's _Unlocking Your Genetic Heritage_ (2004).

Trace Your Roots with DNA.......2007-01-19

Excellent book for the beginner who wants to understand DNA Testing and how to use it for Genealogy.

DNA and Genealogy.......2006-11-03

This publication is a "must have" book for anyone desiring to utilize DNA
to augment their genealogy study.

Genes.......2006-02-22

I enjoyed the book immensely. The book has good information about places that do genetic testing to trace human migration.

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