Book Description
Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics has been thoroughly revised.
*
Part One (Chapters 1-7) covers basic material on DNA structure and function, chromosomes, cells and development, pedigree analysis and the basic techniques used in the laboratory.
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Part Two (Chapters 8-12) discusses the various genome sequencing projects and the insights they provide into the organization, expression, variation and evolution of our genome.
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Part Three
(Chapters 13-18) focuses on mapping, identifying and diagnosing the genetic causes of mendelian and complex diseases and cancer.
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Part Four (Chapters 19-21) looks at the wider horizons of functional genomics, proteomics, bioinformatics, animal models and therapy.
There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of 'Ethics Boxes' to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics.
features:
* Integration of Human Genome Project data throughout the book
* Two new chapters 'Cells and Development' (Chapter 3) and 'Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics' (Chapter 19)
* Completely rewritten and reorganized coverage of complex disease genetics
* Increased emphasis on gene function and on applications of genetic knowledge, including ethical issues
* More prominence given to novel approaches to treating disease, such as cell-based therapies, pharmacogenomics, and personalized medicine
* Special topic boxes that include detailed coverage of ethical, legal and social issues, including eugenics, genetic testing and discrimination, germ-line gene therapy and genetic enhancement, and human cloning
* Contains two indices: a general index and one that contains names of diseases and disorders.
Customer Reviews:
Nice illustrations.......2007-10-11
This book is a pretty good read for thoes with advanced genetics knowledge. It reviews some of the more basic processes in the beginning before diving into the human stuff. As a warning though, it doesnt really hide anything like a beginning bio book so know what your getting yoruself into.
clinical geneticist.......2007-03-12
each addition of this text provides a close to current state of the science review of human molecular genetics, it is an excellent way to update onself about the field.
Excellent Reference Text Book for Moelcular Biology.......2007-02-18
I have used this book earlier for my post-doctoral research work and now I am using this book for the online Medical Laboratory Diagnostic course that I am taking. This is an excellent text book for students and researchers. This book not only offers detailed insight into the fundamentals of human molecular genetics but also gives a review of DNA and chromosome structure and function, cellular development, population genetics, cancer genetics, gene therapy, and different techniques of molecular genetic, its applications, and analyses. The figures and illustrations complement the text very well and are easy to understand. I would highly recommend "Human Molecular Genetics" by Tom Strachan and Andrew P. Read to senior-level college students, undergraduate students, graduate students, technologist working in a Molecular Diagnostic Laboratory and researchers.
Good book, nice figures........2007-02-16
I've only read through chapter 8 so far, but the text is understandable and the figures are clear and helpful--especially in the human genome project chapter, which had the potential to be very confusing.
Excellent reference for students and researchers........2007-01-05
This book offers detailed insight into the fundamentals of human molecular genetics. The contents review DNA and chromosome structure and function, cellular development, population genetics, cancer genetics, gene therapy, and a myriad of molecular genetic techniques, applications, and analyses. The figures and illustrations beautifully complement the text with easily understood captions and legends. The organization of the book is such that the reader can easily find a topic of interest without thumbing through the entire text. I would highly recommend "Human Molecular Genetics" by Tom Strachan and Andrew P. Read to senior-level college students, graduate students, and researchers. This is a must-have in the library of any geneticist.
Book Description
An Introduction to Human Molecular Genetics
Second Edition
Jack J. Pasternak
The Second Edition of this internationally acclaimed text expands its coverage of the molecular genetics of inherited human diseases with the latest research findings and discoveries. Using a unique, systems-based approach, the text offers readers a thorough explanation of the gene discovery process and how defective genes are linked to inherited disease states in major organ and tissue systems. All the latest developments in functional genomics, proteomics, and microarray technology have been thoroughly incorporated into the text.
The first part of the text introduces readers to the fundamentals of cytogenetics and Mendelian genetics. Next, techniques and strategies for gene manipulation, mapping, and isolation are examined. Readers will particularly appreciate the text's exceptionally thorough and clear explanation of genetic mapping. The final part features unique coverage of the molecular genetics of distinct biological systems, covering muscle, neurological, eye, cancer, and mitochondrial disorders. Throughout the text, helpful figures and diagrams illustrate and clarify complex material.
Readers familiar with the first edition will recognize the text's same lucid and engaging style, and will find a wealth of new and expanded material that brings them fully up to date with a current understanding of the field, including:
* New chapters on complex genetic disorders, genomic imprinting, and human population genetics
* Expanded and fully revised section on clinical genetics, covering diagnostic testing, molecular screening, and various treatments
This text is targeted at upper-level undergraduate students, graduate students, and medical students. It is also an excellent reference for researchers and physicians who need a clinically relevant reference for the molecular genetics of inherited human diseases.
Book Description
This book presents a comprehensive and updated catalogue of the already large, and rapidly growing number of chromosome aberrations in man. The consistent structure of the text and references provide for rapid orientation. The catalogue is an important help for any clinician treating patients with autosomal chromosome aberrations as well as for physicians and biologists working in cytogenic laboratories and human genetic institutes.
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Nucleic Acid Testing for Human Disease
Attila, Ed. Lorincz
Manufacturer: CRC
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ASIN: 157444543X |
Book Description
Nucleic Acid Testing for Human Disease describes various techniques including target and signal amplification-based NAT procedures, microarrays, bead-based multiplex assays, in situ hybridization, and SNP techniques. This book discusses RNA expression profiling and laboratory issues such as the need for proper validation of tests intended for routine use. It focuses on specific applications of NATs to human disease diagnosis and treatment, from viral, bacterial, fungal, and protozoan detection to genetic exploration by SNP determinations, patterns of RNA expression, and the growing relevance of epigenetic changes. It also offers different perspectives on future directions in the field.
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DNA Replication and Human Disease (Cold Spring Harbor Monograph) (Cold Spring Harbor Monograph Series)
Melvin L., Ed. DePamphilis
Manufacturer: Cold Spring Harbor Laboratory Press
ProductGroup: Book
Binding: Hardcover
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Biology of Cancer
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Binding and Kinetics for Molecular Biologists
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The Cell Cycle: Principles of Control (Primers in Biology) (Primers in Biology)
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Epigenetics
ASIN: 0879697660 |
Book Description
Cytogenetics is concerned with matching inherited traits with the appearance, structure, and behavior of chromosomes. The first volume, Human Cytogenetics: Constitutional Analysis, covers all aspects of basic human cytogenetic study other than malignancies and acquired abnormalities. The
second volume, Human Cytogenetics: Malignant and Acquired Abnormalities, describes the techniques used to study how chromosomal rearrangements can cause malignancies.
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Molecular Genetics And The Human Personality
Jonathan, Ed. Benjamin
Manufacturer: American Psychiatric Press
ProductGroup: Book
Binding: Hardcover
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ASIN: 0880487550 |
Customer Reviews:
Surprise, surprise!.......2005-05-08
The authors describe two personalities, "harm avoidance" and "novelty seeker." They, and others, have identified the genes responsible for these traits. I have two grandsons less than a year apart. The oldest when crawling on the floor and came to a step, he would not proceed. The other coming less than a year later simply tumbled over the step. At four and five when I took them to the park, the oldest climbed the slide, thought about it and climbed down. He repeated this several times before sliding down. The other simply climbed up and slid down; then tried to climb up the slide. At the Chinese restaurant the eldest will still only eat white rice. The other gobbles everything. The eldest can not ride a bike, the younger has been struggling to ride before he was big enough. The eldest is not at all interested in a driver's license. The younger got his license as soon as he was old enough to apply.
The eldest can perform solo on the stage, publish the school paper, etc, but he avoids harm.
My father was a "novelty seeker" and so was I and one of my three sons. He started international travel at age 16, when he went to spend a year at school in Turkey. He spent his last college year in India. When he traveled Japan he would stay at Buddhist monasteries. He has become an art historian and leads tours to Burma and India. (Can you imagine what his tours are like?) He recently married a Thai.
I never thought much about this personality correlation till I read this book. It is not too technical and I think you will find some of your friends or some of your children described.
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Handbook of Immunohistochemistry and In Situ Hybridization of Human Carcinomas, Vol. 1 (MOLECULAR GENETICS; LUNG & BREAST CARCINOMAS)
M. A., Ed. Hayat
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover
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ASIN: 0123339413 |
Book Description
The various cell types have traditionally been recognized and classified according to their appearance in the light microscope following the process of fixing, processing, sectioning, and staining tissues that is known as histology. Classical histology has been augmented by
immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system.
This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today, ensuring a wide audience for this book.
* The only book available that translates molecular genetics into cancer diagnosis
* Provides the readers with tools necessary to perform and optimize sensitive, powerful techniques, including immunohistochemistry and fluorescence in situ hybridization, used in tumor diagnosis
* Written by experts in this field, the book provides theoretical considerations as well as practical approaches to carry out effectively these techniques
* Offers suggestions, tips, cautions, and guidelines to avoid artifacts and misdiagnosis
* Introduces new techniques to detect genes and proteins involved in the initiation and progression of cancer
* Covers the latest developments and a wide range of applications to the detection of antigens and single-copy DNA and RNA
* Written in a uniform format, each chapter includes Introduction, Materials required, step-by-step detailed Methods, Results, Discussion, and comprehensive up-to-date References
Average customer rating:
- A great book all around
- A must have book for this field
- Essential reading
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Human Evolutionary Genetics: Origins, Peoples & Disease
M. A. Jobling
Manufacturer: Garland Science
ProductGroup: Book
Binding: Paperback
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The History and Geography of Human Genes: (Abridged paperback edition)
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ASIN: 0815341857 |
Book Description
"This is an absolutely superb book! I have been recommending it enthusiastically to professional colleagues, graduate students, and even the occasional highly motivated undergraduate student ever since it was published last year, and the response to the book has been overwhelmingly positive. Not only is the book unique in terms of topical coverage, but it is also extremely well executed. In fact, it is one of the best textbooks on any subject that I have read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguists, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests.
… The text is clearly written, and the illustrations are excellent. The boxed supplementary text is especially informative, whether just explanatory information or an opinion piece by an outside expert. There is a real richness to the mtDNA and Y-chromosome data presented in a phyolgenetic/phylogeographic framework in the three chapters on prehistoric range expansion and global colonization. Students have found chapters 3-6 (about genome diversity) quite helpful and have deemed the text's brief excursions into the realm of mathematics to be effectively presented and not overly technical. Appropriate Web sites are mentioned throughout the book, to foster independent research. I must confess that I learned something new (and important) from every chapter in the book!
… This new compendium emphasizes the enormous explosion in knowledge derived from human haploid systems and molecular genetic markers, and, as such, it is a most worthy successor. It should quickly become the book to consult for genetic information pertinent to the evolution of our species. To the authors, I offer both a sincere thank you and a hearty congratulations for a job well done!"
American Journal of Human Genetics, 76:0, 2005
Customer Reviews:
A great book all around.......2006-07-28
I ordered this book when I first began my research using DNA markers. I found it very easy to read and highly informative, even beyond my own interests. It's a great reference to have around and a must read for anyone working in the field of human genetics, both from a clinical or academic perspective. Its organization lends it suitable for a good textbook in an advanced evolutionary genetics course as well.
A must have book for this field.......2004-08-07
Very up-to-date (msot references are from 2000 to 2003),
and well-written.
You will become an expert in this filed after studying this classic!
I bought a copy for myself, and another one for my advisor.
I have read it twice in a week!
Essential reading.......2004-02-06
Clearly laid out like one of the classic undergraduate textbooks (e.g. Genes VII, Albers et al.), this is the only up-to-date introduction in the field.
The authors make great efforts to link advances in genetics to other fields (e.g. linguistics, anthropology), as well as to organise chapters around key issues such as the spread of agriculture, offering space to key authors in these associated fields. Bibliographic/website sources are also well documented.
Evidently, coverage is broad rather than deep, but if you need some basic background (e.g. I wanted to understand how Y-chromosome sequence data illuminated prehistoric migrations but needed some basic information on microsatellites) before proceeding to original papers, then this is the book for you.
Book Description
Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer.
Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis.
A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point.
In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III.
More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Customer Reviews:
Highly recommended.......2006-04-29
This text is higly informative and readable. Highly recommended for a student of the biology of human cancers. This advanced text gives an overview of the broad range of signaling pathways and mechanisms involved in the formation and progression of tumors. Suitable for graduate students before they embark on a journey exploring the molecular complexities of cancer. Excellent preparatory text for beginning basic science researchers or clinicians who wish to embark cancer research.
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Color Atlas of Genetics (FLEXIBOOK)
Thompson & Thompson Genetics in Medicine, Revised Reprint, 6th Edition
Molecular Biology of the Cell, Fourth Edition
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