Manipulating the Mouse Embryo: A Laboratory Manual

Book Description

Regarded as the "Bible" of mammalian embryo manipulation techniques since the 1986 publication of the first edition of Manipulating the Mouse Embryo: A Laboratory Manual, the third edition of this essential laboratory resource has now been completely reorganized, rewritten, and updated by a new cast of authors. The result is a compilation of new, cutting-edge protocols that include embryonic stem cell production and genetic manipulation, mouse chimeras, mouse cloning, assisted reproduction strategies (including intracytoplasmic sperm injection and in vitro fertilization), whole embryo culture systems, electroporation, embryo and gamete cryopreservation and rederivation, and gene expression, as well as more extensive background information on the use of these techniques. The "gold standard" techniques for applying recombinant DNA technology to investigations of mammalian embryonic development included in the first two editions of this book are also updated and recast, as is the summary of the current state of understanding of mouse development at the molecular level. This book is the premier authoritative and comprehensive source of technical and theoretical guidance for mouse developmental biologists and geneticists and is an essential resource for newcomers to these fields.

Customer Reviews:

The New Testament?.......2004-01-20

A definitive summary of mouse development and simple, concise proven protocols. This is the best publication there is for this kind of work. It's much better than the 2nd, ed. I wish it had more of a troubleshooting focus, but I guess if you are in this line of work, you should be able to figure out problems yourself, or query the tg list.... I like how there are alternative strategies mentioned depending on how your lab is equiped (or not).

International Classification of Rodent Tumours. The Mouse

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Excellent Resource

International Classification of Rodent Tumours. The Mouse
U., Ed. Mohr
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Histopathology of Preclinical Toxicity Studies, Third Edition: Interpretation and Relevance in Drug Safety Evaluation

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Cytokines in the Genesis and Treatment of Cancer (Cancer Drug Discovery and Development)
Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy (Current Topics in Microbiology and Immunology)
Regional Cancer Therapy (Cancer Drug Discovery and Development)

ASIN: 3540645780

Book Description

Regulatory authorities worldwide still depend greatly upon and require long-term animal test results. To improve the reliability of interpretation of such results, a standardized nomenclature for the lesions observed in the tests is essential. Scientists from both academia and industry in many countries have closely cooperated to arrive at a consensus on the descriptions of all the types of tumour and pre-neoplastic lesions encountered in laboratory mice. The series of fascicles should provide information and guidelines especially adapted for international use in practical toxicologic pathology. Images showing the typical appearance of the discussed lesions and references to the most recently published papers complete the presented information.

Customer Reviews:

Excellent Resource.......2001-09-04

This is one of the best books in the field that I have seen. It is a comprehensive classification of tumors in mice. Figures are excellent. The international authors are the leading authorities. It is well worth the price!

The Mouse in Biomedical Research, Volume 1-4, Second Edition (American College of Laboratory Animal Medicine) (American College of Laboratory Animal Medicine)

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The Mouse in Biomedical Research, Volume 1-4, Second Edition (American College of Laboratory Animal Medicine) (American College of Laboratory Animal Medicine)
James G. Fox
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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Similar Items:

The Laboratory Rat (American College of Laboratory Animal Medicine Series)
The Laboratory Mouse: Handbook of Experimental Animals (HANDBOOK OF EXPERIMENTAL ANIMALS)
Flynns Parasites of Laboratory Animals, Second Edition
The Laboratory Fish (Handbook of Experimental Animals)
Pathology of Laboratory Rodents and Rabbits, Third Edition

ASIN: 012369454X

Book Description

In no other species of animal has such a wealth of experimental data been utilized for scientific pursuits. Now in its Second Edition, this Four Volume Set is dedicated to the understanding of the mouse and its role in scientific research. This valuable compendium serves as a standard reference source of information for students embarking on scientific careers, specialists in laboratory animal science, technicians in both animal care and research, and the broad scientific community.

This set is also sold individually and covers History, Wild Mice, and Genetics; Diseases; Normative Biology, Husbandry, and Models; and Immunology.

Volume 1: History, Wild Mice, and Genetics
KEY FEATURES:
A primer for scientists new to the field of mouse research
Information about the history, biology and genomics of the laboratory mouse (Mus musculus)
Mouse origins and relationships covered in chapters on history, evolutionary taxonomy and wild mice
Mouse genetics and genomics discussed in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome
Use of the mouse as a model system for basic biomedical research described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation

Volume 2: Diseases
KEY FEATURES:
New format by discussing specific disease causing microorganisms versus the format used in the first edition which discussed infectious diseases affecting specific organs and tissues
Consists of 26 chapters subdivided into RNA viruses and DNA viruses, mycotic, and parasitic infections.
Provides updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens
Offers information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter

Volume 3: Normative Biology, Husbandry, and Models
KEY FEATURES:
Encompasses 23 chapters with a broad overview on the laboratory mouses normative biology, husbandry, and its use as a model in biomedical research.
Includes chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry.
Discusses management, nutrition, gnotobiotics and disease surveillance
Provides analysis of the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases

Volume 4: Immunology
KEY FEATURES:
A complete new addition to this series, dedicated to mouse immunology including both the innate and adaptive immune systems
Based on the mouse as a choice model when studying immunity in man-arguably more is known about the immune system in mice than any other species except man
Chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells

NEW TO THIS EDITION:
* Over 50% new material
* Each volume contains 4-color page inserts with indispensable figures
* Greatly expanded sections on genetics including: the mouse genome, gene mapping, and gene therapy
* Information on newly recognized disease-causing organisms, such as mouse parvovirus and Helicobacter
* A volume entirely devoted to mouse immunology
* New section on stem cell biology
* Each of the four volumes are available individually

The Laboratory Mouse: Handbook of Experimental Animals (HANDBOOK OF EXPERIMENTAL ANIMALS)

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Invaluable reference book

The Laboratory Mouse: Handbook of Experimental Animals (HANDBOOK OF EXPERIMENTAL ANIMALS)
Hans, Ed. Hedrich
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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Similar Items:

Manipulating the Mouse Embryo: A Laboratory Manual
Mouse Phenotypes: A Handbook of Mutation Analysis
Pathology Of The Mouse
The Laboratory Rat (American College of Laboratory Animal Medicine Series)
The Mouse Brain in Stereotaxic Coordinates, Deluxe Second Edition (with CD-ROM)

ASIN: 0123364256

Book Description

Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimers, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.

One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model.

* Edited by Hans Hedrich, Hannover Medical School
* Comprehensive reference source written by international experts
* Well-illustrated with high quality detailed images
* Two-color, user-friendly format combined with color plate sections

Customer Reviews:

Invaluable reference book.......2007-09-05

This book should be in the lab of every scientist that uses mice in his/her research. My lab was very depressed when I took it to my new job.

Mouse Development: Patterning, Morphogenesis, and Organogenesis

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Mouse Development: Patterning, Morphogenesis, and Organogenesis
Janet, Ed. Rossant
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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Similar Items:

Manipulating the Mouse Embryo: A Laboratory Manual
Atlas of Mouse Development
Anatomical Basis Of Mouse Development
Mouse Phenotypes: A Handbook of Mutation Analysis
The Laboratory Mouse: Handbook of Experimental Animals (HANDBOOK OF EXPERIMENTAL ANIMALS)

ASIN: 0125979517

Book Description

This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.

*Broad-based overview of mouse development from fundamental to specialist levels
*Extensive coverage of a wide range of developmental mutations of the mouse
*Excellent benchmark illustrations of brain, craniofacial, gut and heart development
*In-depth experiment-based assessment of concepts in mammalian development
*Focus on models of specific relevance to human development
*Comprehensive reference to key literature and electronic databases related to mouse development
*High-quality full-color production

A Colour Atlas of the Anatomy of Small Laboratory Animals: Rat, Mouse, Golden Hamster

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A Colour Atlas of the Anatomy of Small Laboratory Animals: Rat, Mouse, Golden Hamster
Peter Popesko , Viera Rajtova , and Jindrich Horak
Manufacturer: Science and Behavior Books
ProductGroup: Book
Binding: Hardcover

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The Laboratory Mouse: Handbook of Experimental Animals (HANDBOOK OF EXPERIMENTAL ANIMALS)
Experimental And Surgical Technique In The Rat
Anatomy and Dissection of the Rat (Freeman Laboratory Separates in Biology)
The Laboratory Rat (American College of Laboratory Animal Medicine Series)
Rat Dissection Manual (Johns Hopkins Laboratory Dissections Series)

ASIN: 0723418233

What's Wrong with My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

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Valuable Book
Essential Book
Expert Review
Review
an excellent resource

What's Wrong with My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice
Jacqueline N., PhD Crawley
Manufacturer: Wiley-Liss
ProductGroup: Book
Binding: Hardcover

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Mouse Phenotypes: A Handbook of Mutation Analysis
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The Behavior of the Laboratory Rat: A Handbook with Tests

ASIN: 0471316393

Book Description

Transgenic and knockout mutations provide an important means for understanding gene function, as well as for developing therapies for genetic diseases. This engaging and informative book discusses the many advances in the field of transgenic technology that have enabled researchers to bring about various changes in the mouse genome. Equal emphasis is given to both the principles of transgenic and knockout methods and their applications. A clear and concise format provides researchers with a comprehensive review of the behavioral paradigms appropriate for analyzing mouse phenotypes.

What's Wrong with My Mouse? explains the differences between transgenic knockout mice and their wild-type controls, while providing critical information about gene function and expression. This volume recognizes that newly identified genes can provide useful insights into brain functioning, including brain malfunctioning in disease states. Written by a world-renowned expert in the field, the material also covers:
* How to generate a transgenic or knockout mouse
* functions (open field, holeboard, rotarod, balance, grip, circadian activity, etc.)
* Sensory abilities (olfaction, vision, hearing, taste, touch, nociception)
* Reproductive behavior, social behavior, and emotional behavior

Researchers in neuroscience, pharmacology, genetics, developmental biology, and cell biology will all find this book essential reading.

Customer Reviews:

Valuable Book.......2002-11-19

"...this valuable book is currently the most complete overview of behavioral procedures available...it is a must have and a must read book..." (Genes, Brain, and Behavior, 2002)

Essential Book.......2001-07-24

"I would recommend that every behavioral scientist has at least two copies, one for their own use and one that will be on permanent loan to their students, post-doctoral students and colleagues in molecular biology." -- TRENDS in Pharmacological Sciences (Gerard R. Dawson, Merck Sharp & Dohme Research Laboratories)

Expert Review.......2001-07-24

"[T]his volume succeeds as a useful introduction to the realm of behavioral phenotyping for those interested in creating or using the large and increasing number of promising targeted mutant mice." -- TRENDS in Neurosciences (John K. Belknap, Oregon Health Sciences University)

Review.......2000-06-15

It is a much prized addition... and fulfills a heretofore unmet need for a comprehensive sourcebook of mutant mouse literature and procedures. In addition to its reference utility, Dr. Crawley's text can exert a valuable influence on the future of transgenic and knockout mouse research by standardizing behavioral phenotyping methods according to the present state-of-the-art. --Stephen C. Heinrichs, Ph.D., Boston College

an excellent resource.......2000-06-08

Very timely given the increasingly recognized importance of providing behavioral phenotypes of mutant mice. I would recommend the book with enthusiasm. --Eric Nestler, Yale University School of Medicine

Systematic Evaluation Of The Mouse Eye: Anatomy, Pathology, and Biomethods (Research Methods for Mutant Mice Series)

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Systematic Evaluation Of The Mouse Eye: Anatomy, Pathology, and Biomethods (Research Methods for Mutant Mice Series)
Richard S., Ed. Smith
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 084930864X

Book Description

The high degree of similarity between mouse and human genomes and physiology has made mice the laboratory animals of choice in the search for models of human disease. In recent years, significant advances in our ability to examine the mouse eye and to view vascular and neural structures in vivo has led to a marked increase in interest in mouse ocular pathology and development. This book provides the first comprehensive and systematic approach to understanding the development, structure, and abnormal pathology of the mouse eye. It describes the normal anatomy, pre- and postnatal development, regional pathology, and methodology for evaluation of the mouse eye and adnexae.

Mouse Genetics and Transgenics: A Practical Approach

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Mouse Genetics and Transgenics: A Practical Approach
I.J., Ed. Jackson
Manufacturer: Oxford University Press
ProductGroup: Book
Binding: Hardcover

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Transgenic Mouse Methods and Protocols (Methods in Molecular Biology (Cloth))
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ASIN: 0199637083

Book Description

A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: APA covers all aspects of using the mouse as a genetic model organism: care and husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; and gene targetting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.

Histological Atlas of the Laboratory Mouse

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Histological Atlas of the Laboratory Mouse
William D. Gude
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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