Cytokine Reference: A Compendium of Cytokines and Other Mediators of Host Defense (Individual Version)

Book Description

The Cytokine Reference is the most complete work for anyone interested in the role of cytokines in host defense processes. With essential and comprehensive information on all known cytokines, including chemokines, growth factors and neuropeptides, the database will include hundreds of entries with detailed descriptions of cytokine genes, proteins, cell sources, activities, receptors, receptor signal transduction, gene activation, pathophysiology, therapeutics and techniques. This encyclopedic reference is written by a panel of global experts and will include extensive tables and diagrams. This book/online bundle consists of a two-volume print set, plus a regularly updated and searchable Online Database.
Cytokines are produced by virtually all the cells in our bodies, and they regulate the systems that defend us against infection, tumors, and trauma. This publication and database will enable all those working in the field to find the information they need about this ever-expanding field.

* Online extensively-linked database is highly functional and allows you to reach data in a variety of ways--by cytokine, by cell type, or by disease
* Online version offers regularly updated entries and addition of new entries as research uncovers further information
* Print version has approximately 2500 pages of detailed and highly structured information on all the cytokines and other mediators of host defense
* Contains over 175 chapters contributed by international experts and edited by 6 world renowned scientists
* Online database allows extensive links at chapter subheading level guiding you through the maze of inter-relationships
* Online version includes full color diagrams and sequences plus links to online databases, including MEDLINE, PDB, SWISSPRO, and GenBank
* Every cytokine or receptor chapter uses the same highly structured subheadings, ensuring that the information is complete, comprehensive, and easy to find

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Biochemistry Of Cell Signalling
Ernst J. M. Helmreich
Manufacturer: Oxford University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0198508204

Book Description

The Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ss in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response. As phosphorylation - dephosphorylation is involved in nearly all cellular regulatory processes, Part 1 concludes with a synopsis of its role in signalling. Part 2 describes the implementation of the signalling cascades focusing on the effect on gene transcription. After a brief description of the transcriptional machinery the regulation of transcription by cytokines and growth factors in the control of cell growth and the mechanisms and sites of control are discussed in detail. The regulators discussed include Jun/Fos, NF-AT, SREBPs, and STATs. The next two chapters cover gene regulation by nuclear receptors, including both the steroid hormone receptors and non-steroid nuclear receptors e.g. the retinoic acid receptors RAR and RXR. Part 3 studies the global cellular regulatory programs for the control of cell growth and proliferation. The first chapter concerns the regulation of the cell cycle and the role of the cyclin-dependent kinases, telomerase, Ran, and cell cycle checkpoints. The next topic is the signalling pathways in apoptosis: the TNF-receptor family death receptors, caspases, and the intracellular apoptosis signals and the role of apoptosis in the lifecycle of cells. Part 3 ends with a discussion of the signal pathways involved in the immune response, focusing on the involvement of cell-cell interactions. Part 4 considers loss of regulatory control and its consequences with respect to the molecular basis of cancer. It first describes the cellular regulatory proteins that have oncogenic potential, how they can become oncogenic and cause the transformation of normal cells to cancerous cells. Next is an analysis of the loss of developmental controls, the APC protein, ss-catenin, and the Wnt pathway, that lead to mature terminally differentiated cells reverting to immature embryonic cells. The book ends with a summary of the molecular and cellular causes of cancer and an outlook for novel therapies. Throughout the text, the emphasis is on structure and mechanism and is well illustrated with 200 figures. The Biochemistry of Cell Signalling will be an invaluable companion to all graduate students studying cell signalling.

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Feel Good
This time it was my husbands turn to lose weight....
Bottom Line, Does it Work? Yes it Does
Buy the Book and Apply It Daily
Lose your weight, not your mind

The Feel-Good Diet
Cheryle R. Hart , and Mary Kay Grossman
Manufacturer: McGraw-Hill
ProductGroup: Book
Binding: Hardcover

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ASIN: 0071453784

Book Description

No cravings. No stress. No fatigue.
Finally, a diet you can feel good about!

Introducing The Feel-Good Diet, a scientific breakthrough in weight loss that will help you:

Turn off your hunger
Turn on your energy
Tone up your body
And "yo-yo" no more!

The Feel-Good Diet is a revolutionary weight-loss program that works with you, not against you. Cheryle Hart, M.D., and Mary Kay Grossman, RD, reveal that many other diets cut out essential carbs and pack on too much protein, which depletes your brain's neurotransmitters, especially serotonin. This "yo-yo brain" effect zaps your willpower and leaves you irritable, depressed, and carbo-craved.

The Feel-Good Diet helps you battle "yo-yo brain" and finally win your war with your weight. With a few simple guidelines and easy-to-prepare menus, you can eat delicious, healthy foods that actually boost your serotonin levels--so you can lose weight, end cravings, reduce stress . . . and feel good.

Customer Reviews:

Feel Good.......2007-07-29

The authors take the yo-yo weight loss and weight gain syndrome out of the equation with a comprehensive look at hormone related stress factors and weight gain on the reader's body. With detailed explanation on why this occurs and how to prevent weight gain from repeating by balancing out your diet with proper foods.
The Feel Good Diet teaches the reader how to improve eating habits for a healthier, well balance eating lifestyle.

This time it was my husbands turn to lose weight...........2007-05-29

Everyone knows I am the biggest fan of Cheryle R. Hart and Mary Kay Grossman for writing The Insulin-Resistance Diet book which forever changed my life.

After losing 40+ pounds on my own and still having high cholesterol and still being 60 pounds overweight (not to mention feeling terrible) I needed answers. My OB/GYN found the problem and suggested The Insulin-Resistance Diet book by Hart and Grossman. I am now a total of 100 pounds lighter (50+ pounds thanks to the Insulin Resistance Diet), my cholesterol is normal and my Insulin levels are normal. I have kept the weight off for 2 years and couldn't love my life more.

My husband on the other hand had a much harder time over the Holidays and I decided The Feel Good Diet was what he needed to take off the weight. The two of us loved the book because it spoke to us from different angles. My husband is very analytical and likes to know how the clock works, I on the other hand, just want to know what time it is. The Feel Good Diet works because it gives you the "why" and "how" all in one book.

The biggest change for me was the quality of sleep I now enjoy after having my Evening Seretonin-Boosting Snack. The S'More Serotonin Snack is to die for or an evening watching a movie while snacking on popcorn made my husband very happy. The other significant change was our energy levels in the afternoon by incorporating the afternoon snack.

Cheryle Hart and Mary Kay Grossman not only wrote books which allowed me to lose weight and changed my life but they educated me about my body and empowered me to be able to keep the weight off. To be able to live a life where you control your weight instead of the food controlling your weight is AMAZING!!!!

Bottom Line, Does it Work? Yes it Does.......2007-04-28

People who have dieted as long as I have know about dieting. We've read the new books, tried new ways of dealing with our persistent problem.
Normal weight people must find this confusing if they think at all about our dilemma. Why can't we just -get- the basic principle that you eat less than you expend to lose weight. Simple. Unfortunately, not that simple in our nation. Not that simple for bodies out of whack.
It is mysterious to me how people can just eat to live and not think about it 24/7. How freeing it must be to spend no time planning meals, logging calories in and out, making weight goals, etc.etc. I may never reach that level of normalacy but the principles in this book and it's predecessor The Insulin Resistance DietThe Insulin-Resistance Diet : How to Turn Off Your Body's Fat-Making Machine, help me see what is possible.
As a dieter I want to know one thing before I put money out on a new diet book. Does it help, does it work? Is this book going to give me some vital piece of information that will help me change my life? The answer to those questions is yes, this book does help,work and give vital information. The authors encourage you to change by slowly changing one new behavior at a time until you've changed your habits even if this process takes months. We want what we want when we want it which is usually now, but that is a formula for failure in any major life change.
I didn't expect this book to be significantly different from Dr. Hart and Ms Grossman's first book, The Insulin Resistance Diet but it is. If possible, I really recommend buying both books and reading the Insulin Resistance Diet first. Although the Feel Good Diet continues and expounds upon the material in the Insulin Resistance Diet, both books stand on their own. The Feel Good Diet is better understood if you read the Insulin Resistance Diet first. If you don't want to buy the Insulin Resistance Diet, go to your public library. The IR Diet is the philosophical underpinning for the Feel Good Diet. When you eat the Insulin Resistance way, there is a calm that settles over you which makes your life and the changes you'll be making so much easier.
I also suggest reading this book completely through before trying ANY of the suggestions. Don't go off half cocked, as I did. The apple cider vinegar Vinegar, Apple Cider, Unfiltered, Raw, Organic, 32 oz.works and works well. In my opinion, it doesn't taste bad either. You might add low glycemic agave nectarAgave Nectar Liquid Sweetener, Light, Squeeze Bottle, Organic, 8 oz., to sweeten rather than other, especially artificial, sweeteners. I don't use a sweetener. It's helpful to increase your intake of minerals before you start on the vinegar. The book lists natural sources of minerals. It is also good to increase the supplements you take as suggested in the book before you start taking the 5HTP.
The book talks about sublingual 5HTP in the form of craniyums. I have benefited from 5HTPSecrets of 5-HTP: Nature's Newest Super Supplement, it gives me time to make better food choices and drastically lowers my chocolate cravings. Although I do have some stomach upset when taking regular 5HTP I am still in the early stages of deciding whether craniyums are a better source of 5HTP. Not everyone has stomach problems with 5HTP. Most of the serotonin receptors in the body are in the gut area, the second brain, as Dr. OZ says.
This book has simple menus which help you reorganize your eating, it deals with acid, alkaline issues which are very important for overall health and it deals in detail with why we need increased serotonin and dopamine precursors to be successful at dieting. All of this is sanely given with an understanding that major changes do not happen overnight.
I found out that I suffer with Seasonal Affective Disorder about 10 years agoWinter Blues, Revised Edition: Everything You Need to Know to Beat Seasonal Affective Disorder. I know what low serotoin feels like but didn't connect it with insulin resistance until I read The Insulin Resistance Diet about a year ago. Most of the weight I've gained has happened in the winter of each year when my serotonin is extremely low. If you gain 10 lbs a year over a period of many years, you end up with a weight problem. If you use food to supply the brain chemicals you need to feel good, you end up with a weight problem. And weight problems eventually lead up to many, many other physical, mental, emotional and relational problems, as we all know.
So bottom line, yes I do recommend this book.

Buy the Book and Apply It Daily.......2007-03-08

The Feel Good Diet by Hart MD and Grossman RD
by Dr. Joseph S. Maresca PhD

Overall, the book is well-researched. The findings make sense. There are good references cited from authoritative journals; namely,

- American J of Physiology
- Nutrition and American J of Clinical Nutrition
- European J of Pharmacology and Endocrinology
- J of Psychosomatic Research
- J of the American Dietetic Association
- J of Affective Disorders and J of Transmissions - Brain Research
- Exercise and Sports Science Reviews and many others

In the authors' next book, I would include some citations from The Lancet.

The book claims to assist in crafting a personal diet regimen that boosts serotonin,improves mood and maintains the weight loss into the future. Serotonin improves well being, controls cravings and contributes materially to the sense of well being.

The authors describe how serotonin is made via minerals and cofactor vitamins. Certain habits and foods contribute toward a neurotransmitter deficiency by the authors. These aspects include smoking, drinking, sugar, starch, chocolate,tobacco and carbs by late afternoon or evening. The thyroid and testosterone are the hormones of the metabolism. Testosterone can be measured via saliva or blood testing. DHEA or medications can be taken orally to increase the production of testosterone according to the authors. Calcium in the carbonate form is the preferred vitamin for weight loss together with stress control.

Plain or low fat yogurt has the highest calcium (Ca.) content according to
the authors. The low insulin spike foods are meats (low fat) , fish, poultry, eggs,low fat/sugar dairy, legumes, dried beans, nuts and seeds. There is an extensive section on sample foods. Omega 3 and 6 are the preferred "good fats". Super pH water is known to boost metabolism. More sample recipes are listed in Chapter 14.

After having had numerous medical encounters, I consolidated the advice of several physicians and my personal experience into a food/lifestyle profile which has helped me. This includes the following:
o frequent exercise (cardio and cycling)

o control over late day eating or eating after 8 PM

o bottled water, tea, caffeine-free coffee, occasional diet soda, low alcohol content white or red wine AS GOOD SUBSTITUTES for canned soda,
coffee with caffeine, higher content alcohol (> 10%)

o plantains, nuts and seeds as a substitute for potato chips and pop corn

o low triglyceride restaurant foods

o control over gluten consumption

o less protein to control proteinuria and protect the kidneys

o sugar free candies as a substitute for candy bars of all kinds and snack cravings

This regimen (by my own personal experience ) will take off 20-30 pounds permanently and improve blood chemistry in the area of glucose control, the SED RATE, the triglyceride totals and several other blood factors. It will help with the micro-crystalline measurements done by the Endocrinologist for pre-diabetic states. Long term application may help with the more chronic forms of progressive diabetes , pancreatic damage and
chronic diverticulitis which impacts everyone incrementally after age 40.

The book is recommended highly for anyone beginning the process of life-long weight management and/or more healthful eating. The acquisition is priced reasonably.

Lose your weight, not your mind.......2007-02-01

Cheryle Hart, M.D. writes a very compelling book. The part that really speaks to me is the part about how while on Atkins I may have lost weight, but I also felt a little off, even a little depressed. Now I know that because I did not have enough Carbs, I lost serotonin, and like she said I lost my mind. While the book seems to be aimed towards women, it has been very helpful to me, too. Now I have two ways to increase my serotonin. One way is to eat my serotonin raising snacks and if that is not enought, I can get neurotransmitter precursors like 5-HTP and tyrosine. Thank you Dr. Hart.

Receptors: Models for Binding, Trafficking, and Signaling

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Excellent kinetics book
A book for the modern biologist

Receptors: Models for Binding, Trafficking, and Signaling
Douglas A. Lauffenburger , and Jennifer Linderman
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0195106636

Book Description

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.

Customer Reviews:

Excellent kinetics book.......2005-09-22

If you are thinking of purchasing a book on receptor-ligand kinetics, this is a wise choice. It is easy to follow and advanced enough for most graduate work in biochemical and biomedical engineering.

A book for the modern biologist.......2004-04-23

This book will surely be thought of as the first structured presentation of principles of modern systems biology. This book introduces the application of Chemical Engineering to biologists and molecular biology and pharmacology of receptors to Chemical Engineers. The top-down picture of coupled processes is not only new to biologists but introduces a whole new way to look at biological problems. Especially the chapter which has cell migration explained introduces one to multi-dimensional thinking: cell mechanics, biochemistry, kinetic modeling and molecular biology all in the same problem. This may seem mystical to many. Would probably be read more by Engineers than biologists, who are yet to take the leap in thought to multi-dimensional science.This book would be remembered after many years to be a pioneer in the new science of systems biology, although it was written much before the Human Genome Project. Systems thinking and Chemical Engineering has been much beneficial in solving some very important biomedical problems like Drug Delivery(Robert Langer), Tumor Biology(Rakesh Jain) and Tissue Engineering(Robert Langer et.al.). Lauffenburger's work would be counted among these shining lights when these methods and tools bear fruit sooner than later.(Lauffenburger has already provided a glimpse of success of this approach when he worked with Amgen to produce a much pharmacokinetically improved biologic using physiologically based pharmacokinetic model coupled with cellular modeling of receptor-ligand trafficking and binding model)Nature,5 August 2002.Lauffenburger and Linderman are geniuses seeking support for "return to science" for biology.

Cell Surface Receptors: A Short Course on Theory & Methods

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Cell Surface Receptors: A Short Course on Theory & Methods
Lee E. Limbird
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 0387230696

Book Description

Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.

Hazardous Wastes: Sources, Pathways, Receptors

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Excellent book
Book Review- Hazardous Wastes, Richard Watts

Hazardous Wastes: Sources, Pathways, Receptors
Richard J. Watts
Manufacturer: Wiley
ProductGroup: Book
Binding: Paperback

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ASIN: 0471002380

Book Description

A fundamental approach to the scientific principles of hazardous waste management and engineering, with the study of both currently-generated hazardous wastes and the assessment and characterization of contaminated sites.

Customer Reviews:

Excellent book.......2005-03-04

This text is a must for any practicing engineer who works with hazardous materials. Ample reference sections and thorough, well written explanations in the text make this book the first place I look for information when confronted with a problem now that I am in the "real world," but also when I was still in school.

Topics covered in the text include:
Environmental regulations (basics, list of EPA acronyms)
Environmental chemistry (structures/naming of organics,pKa's, solubility, chemical incompatibility, etc)
Chemical behavior in the environment (sorption, retardation, partioning, volatilization, henry's law, etc)
Science behind abiotic and biotic transformations (radical rxns, hydrolysis, kinetics, etc)
Toxicology (good overview)
Remedial technologies and strategies (chemical oxidation, solidification, bioremediation, etc)

Appendices have data for most contaminants of concern on topics such as:
Mean water solubility
Vapor pressure
Henry's law constant
Kow
Specific gravity
Saturation concentration in air
Slope factors and RfDs

One of the best books I own.

Book Review- Hazardous Wastes, Richard Watts.......2004-06-16

As a practicing environmental engineer, I find that this book continues to be an invaluable reference source.
While the organization and text make for quick review of fundamental concepts, the appendices alone justify the purchase price.

Paul Erlich's Receptor Immunology: The Magnificent Obsession

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Paul Erlich's Receptor Immunology: The Magnificent Obsession
Arthur M. Silverstein
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0126437653

Book Description

This book describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field.

the selectionist theory of antibody formation
kinetics of primary and secondary antibody response
quantitative methods of measurement of antigens and antibody
demonstration of passive transfer of immunity from mother to foetus

Dopamine Receptors and Transporters: Function, Imaging, and Clinical Implication, Second Edition, (Neurological Disease & Therapy)

Average customer rating:

The correct subtitle is: Function, Imaging, and Clinical Implication

Dopamine Receptors and Transporters: Function, Imaging, and Clinical Implication, Second Edition, (Neurological Disease & Therapy)

Manufacturer: Informa Healthcare
ProductGroup: Book
Binding: Hardcover

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Book Description

"Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."

Customer Reviews:

The correct subtitle is: Function, Imaging, and Clinical Implication.......2006-09-02

The subtitle of the listed volume "Dopamine Receptors and Transporters" (2nd Edition, 2003, edited by Anita Sidhu, Marc Laruelle, and Philippe Vernier) is "Function, Imaging, and Clinical Implication". (The series is "Neurological Disease and Therapy," of which this is volume 56.)

(See "look-inside" image.)

Average customer rating:

comprehensive and clear

Transmitters And Drugs In Cns Function
Roy Webster
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471978191

Book Description

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions.

It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

Customer Reviews:

comprehensive and clear.......2005-03-13

This is the only sourcebook in the market that both explains in detail the action of neurotransmitters and considers the implication of that action on behaviour. Moreover it's a well written book worth the price.

Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts

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Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts
H. Gutfreund
Manufacturer: Cambridge University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 052148586X

Book Description

This book introduces the reader to the kinetic analysis of a wide range of biological processes at the molecular level. It shows that the same approach can be used to resolve the number of steps for a wide range of systems including enzyme reactions, muscle contraction, visual perception, and ligand binding. The author discusses the methods for characterizing these steps in chemical terms. Firmly rooted in theory, a wide range of examples and experimental techniques are introduced as well. A historical approach is used to demonstrate the development of the theory and experimental techniques of kinetic analysis in biology.

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