Guide to Manuscripts in the Western History Collections of the University of Oklahoma

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Power of the Land is the first in-depth look at the past 120 years of struggle over the Oglala Lakota land base on Pine Ridge Indian Reservation in South Dakota. An unholy alliance between the federal government and regional economic interests has led to progressive disenfranchisement of the majority of the Oglala people, and to the development of an ethnically distinct class of Oglala who control the Pine Ridge Indian Reservation land base. Understanding the resulting conflicts is key to understanding the reservation situation as a whole.

Book Description

The now completed Second Edition of the Biotechnology book series is the largest source of information in the field consisting of approximately 11 000 printed pages and ca. 500 contributions. Everybody involved in biotechnology will appreciate this book series at their fingertips. Clear, concise, and comprehensive Biotechnology gives scientists all the background material which is indispensable for the development of biotechnological processes. It offers a unique collection of current information on all aspects in biotechnology research and development from biological and genetic fundamentals to genomics, bioinformatics, special processes, metabolism and legal, economic and ethical dimensions. Such a huge amount of material requires easy access to the keywords, many of which are treated in different volumes. Therefore the cumulative index is a valuable and convenient tool for search throughout the whole set of volumes.
Topics included are Biological Fundamentals/ Genetic Fundamentals and Genetic Engineering/ Bioprocessing/ Measuring, Modelling, and Control/ Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes/ Genomics and Bioinformatics/ Products of Primary Metabolism/ Products of Secondary Metabolism/ Biotransformations, Enzymes, Food, and Feed/ Special Processes/ Environmental Processes/ Legal, Economic and Ethical Dimensions/ Cumulative Index

Novel Therapeutic Proteins: Selected Case Studies

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Novel Therapeutic Proteins: Selected Case Studies
Klaus, Ed. Dembowsky
Manufacturer: JOHN WILEY
ProductGroup: Book
Binding: Hardcover

Biochemistry | Biological Sciences | Science | Subjects | Books

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ASIN: 3527302700

Book Description

This book describes medical applications of recombinant proteins and monoclonal antibodies, some of which have already been on the market for several years while others have only recently been launched. It also highlights the manufacturing processes for individual products, the strategies that were taken by companies in the clinical development, and the hurdles that were encountered in clinical trials and had to be overcome before approval by regulatory authorities. Finally, this book illustrates strategies to modify and improve the pharmacodynamic and pharmacokinetic properties of naturally occurring proteins thus paving the way for a new era in biotechnology.
Foreword written by JÃ¼rgen Drews.

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Please add color !!

Recombinant Antibodies
Frank Breitling , and Stefan Dübel
Manufacturer: Wiley-Spektrum
ProductGroup: Book
Binding: Paperback

Genetics | Evolution | Science | Subjects | Books

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ASIN: 0471178470

Book Description

As new recombinant DNA technology continues to join with cellular and molecular immunology, the field of antibody engineering has become a flourishing discipline. Antibody genes are now being cloned, genetically manipulated, and expressed to produce antigen binding proteins. Recombinant Antibodies addresses this burgeoning field with its comprehensive survey of the developing possibilities for producing specific antibodies by combinatorial methods.

Following a comprehensive introduction to the field, the book is divided into four parts: a detailed introduction to the underlying concepts of recombinant antibodies, a description of the various methods for the generation of recombinant antibodies, their production and purification, and various designs and applications of genetically engineered proteins. The combination of these techniques substantially extends the functionality of natural antibodies. In addition, the book will focus on:
* Hybridoma immortalization.
* Generation and functional screening of highly complex antibody gene libraries.
* Human monoclonal antibodies to highly toxic and pathogenic antigens.
* Improving specificity or affinity of antibodies.
* New agents for cancer diagnosis and therapy.
* Genetic fusions for the production of bi- and multifunctional molecules.
* Production of large quantities of recombinant antibodies.
* New methods of purification.
* Emerging technologies.

Recombinant Antibodies is the first general overview of the emerging field of antibody engineering and will serve as the definitive source for researchers and engineers in biology and medicine, biochemistry, immunology, and molecular biology, as well as anyone who is interested in biotechnology and antibody engineering.

Customer Reviews:

Please add color !!.......2001-06-27

I just received this book, and although the content does meet my expectations, I must say that some figures are of disappointing poor quality (3D protein representation for instance). I haven't seen the original German version, but it looks as if the English (American) editor has saved a few bucks by simply copying the figures on a B&W copy machine. This is outrageous ! We are living in the 21st century, and any 10 years old computer geek is capable of producing high quality color figures with a decent scanner ! Given the price (70 dollars !), I can't give more that 2 stars !

Recombinant Antibodies for Cancer Therapy: Reviews and Protocols (Methods in Molecular Biology (Cloth))

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Recombinant Antibodies for Cancer Therapy: Reviews and Protocols (Methods in Molecular Biology (Cloth))
Martin Welschof
Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

Experiments & Projects | Experiments, Instruments & Measurement | Science | Subjects | Books

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ASIN: 0896039188

Book Description

In Recombinant Antibodies for Cancer Therapy: Methods and Protocols, Martin Welschoff and JÃ¼rgen Krauss present a collection of carefully selected protocols for the design, construction, and characterization of novel anticancer therapeutics based on recombinant antibody technology. These readily reproducible methods include coverage of hybridoma-derived recombinant antibodies, recombinant antibody fragments from phagemid-displayed antibody repertoires, antibody fragments with additional properties, and large-scale production of recombinant antibodies for clinical applications. Concise review articles also survey the current status of recombinant antibodies in cancer therapy, as well as the generation of antibody molecules through antibody engineering.

Recombinant Antibodies: Applications in Plant Science and Plant Pathology

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Recombinant Antibodies: Applications in Plant Science and Plant Pathology
Karen, Ed. Harper
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

Biotechnology | Biological Sciences | Science | Subjects | Books

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Book Description

The first part of this book combines basic information on antigens and antibodies with a review of technologies for both the development of recombinant antibodies and their application. The principles involved in producing recombinant antibodies from either pre-existing monoclonal antibodies or from phage display libraries are introduced with practical examples. Modern methods for the analysis of antibody binding properties are described in detail. Examples are given in the second part of this book for the application of recombinant antibody technology to antibody-mediated resistance to plant disease and immunomodulation of plant antigens. The potential of antibody-expressing plants as bioreactors for large-scale production and storage of recombinant antibodies is described and a future outlook given.

Recombinant Proteins, Monoclonal Antibodies & Therapeutic Genes

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Recombinant Proteins, Monoclonal Antibodies & Therapeutic Genes
A., Ed. Mountain
Manufacturer: QUALITY RESOURCES
ProductGroup: Book
Binding: Hardcover

Biochemistry | Biological Sciences | Science | Subjects | Books

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Biotechnology | Special Topics | Medicine | Subjects | Books
ASIN: 3527283153

Book Description

In the field of medicinal biotechnology three major developments have caused a revolution in research that has a lot of innovative effects on clinical medicine and future applications on humans. With the availability of tailored recombinant proteins and the opportunity to produce high amounts of monoclonal antibodies new diagnostic applications have emerged and many therapeutic perspectives, e.g. in the treatment of multiple sclerosis and of cancer, are being discussed today.
The aim of somatic gene therapy is to re-establish normal cell function by supplying the cells with the respective intact gene. This is a very difficult task and different diseases, e.g. AIDS and several metabolic disorders, are under investigation now. So far first promising approaches exist in cancer therapy.
Moreover the book informs about regulatory and economic aspects of these new methods and their applications.

Application of a multi-sulfonamide biosensor immunoassay for the detection of sulfadiazine and sulfamethoxazole residues in broiler serum and its use as ... [An article from: Analytica Chimica Acta]

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Application of a multi-sulfonamide biosensor immunoassay for the detection of sulfadiazine and sulfamethoxazole residues in broiler serum and its use as ... [An article from: Analytica Chimica Acta]
W. Haasnoot , M. Bienenmann-Ploum , U. Lamminmaki , and S
Manufacturer: Elsevier
ProductGroup: Book
Binding: Digital

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ASIN: B000RR6YR4

Book Description

This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
A multi-sulfonamide biosensor immunoassay (BIA), based on a previously developed mutant antibody (A.3.5) in an optical biosensor (Biacore 3000), was applied to analyse the serum and plasma samples obtained from the broilers treated with sulfamethoxazole and sulfadiazine. The assay was fast (5min per sample), the sample preparation easy (dilution in antibody containing buffer only) and an equal sensitivity for the two sulfonamides was obtained with limits of detection (LOD) in serum and plasma below 10ngml^-^1. The concentrations found with the BIA in serum and plasma of the treated broilers were comparable and higher than the concentrations found in the tissue by LC-MS/MS. The average serum/tissue ratios for sulfamethoxazole were 6.2 (leg meat), 2.5 (liver) and 1.3 (skin+fat) and for sulfadiazine 8.7 (leg meat), 3.1 (liver) and 2.2 (skin+fat). To predict the concentrations of the two sulfonamides below the maximum residue limit (MRL) of 100ngg^-^1 in the tissue with the highest level (skin+fat), the proposed action level of the multi-sulfonamide BIA in serum is 130ngml^-^1. A later developed mutant antibody (M.3.4), with a better sensitivity towards more sulfonamides, was applied during a survey. Serum samples (n=300) of broilers from 30 different flocks were found negative. Concentrations between <5 and 152ngml^-^1 (sulfamethoxazole equivalents) were found in the serum samples of one flock (n=160) with an average of 25+/-21ngml^-^1. The sulfonamide identified by LC-MS/MS in these samples was sulfamethoxazole.

Comparison of multi-sulfonamide biosensor immunoassays [An article from: Analytica Chimica Acta]

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Comparison of multi-sulfonamide biosensor immunoassays [An article from: Analytica Chimica Acta]
M. Bienenmann-Ploum , T. Korpimaki , W. Haasnoot , and Ko
Manufacturer: Elsevier
ProductGroup: Book
Binding: Digital

Elsevier | By Publisher | e-Docs | Formats | Books
ASIN: B000RR3G52

Book Description

This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Three different group-specific anti-sulfonamide antibodies were compared in inhibition assay formats in an optical biosensor (BIACORE 3000) using CM5 sensor chips coated with three different sulfonamide derivatives. The antibodies used were an anti-sulfamethazine monoclonal antibody (Mab) 21C7, the sulfonamide binding protein (SBP) in the Qflex Kit Sulfonamides and a recently developed mutant antibody (M.3.4). Each of these antibodies showed interactions with all 17 sulfonamides tested and one (Mab 21C7) was sensitive for the N"4-acetyl metabolites also. The limits of detection of the different sulfonamides in chicken serum varied between 7 and >1000ngml^-^1 (Mab 21C7), 15 and 340ngml^-^1 (Qflex) and 4 and 82ngml^-^1 (Mutant M.3.4). The mutant M.3.4 based assay was found to be the most sensitive towards most of the sulfonamides whereas the Qflex Kit Sulfonamides detected the five sulfonamides registered for application in poultry in The Netherlands within the narrowest measurement range.

Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic ... Biochemistry and Physiology, Part C]

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Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic ... Biochemistry and Physiology, Part C]
R.R. Merson , D.G. Franks , S.I. Karchner , and M.E Hahn
Manufacturer: Elsevier
ProductGroup: Book
Binding: Digital

Elsevier | By Publisher | e-Docs | Formats | Books
ASIN: B000RR6JII

Book Description

This digital document is a journal article from Comparative Biochemistry and Physiology, Part C, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
The aryl hydrocarbon receptor (AHR) and AHR repressor (AHRR) proteins regulate gene expression in response to some halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons. The Atlantic killifish is a valuable model of the AHR signaling pathway, but antibodies are not available to fully characterize AHR and AHRR proteins. Using bacterially expressed AHRs, we developed specific and sensitive polyclonal antisera against the killifish AHR1, AHR2, and AHRR. In immunoblots, these antibodies recognized full-length killifish AHR and AHRR proteins synthesized in rabbit reticulocyte lysate, proteins expressed in mammalian cells transfected with killifish AHR and AHRR constructs, and AHR proteins in cytosol preparations from killifish tissues. Killifish AHR1 and AHR2 proteins were detected in brain, gill, kidney, heart, liver, and spleen. Antisera specifically precipitated their respective target proteins in immunoprecipitation experiments with in vitro-expressed proteins. Killifish ARNT2 co-precipitated with AHR1 and AHR2. These sensitive, specific, and versatile antibodies will be valuable to researchers investigating AHR signaling and other physiological processes involving AHR and AHRR proteins.

Enzyme-amplified protein microarray and a fluidic renewable surface fluorescence immunoassay for botulinum neurotoxin detection using high-affinity recombinant ... [An article from: Analytica Chimica Acta]

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Enzyme-amplified protein microarray and a fluidic renewable surface fluorescence immunoassay for botulinum neurotoxin detection using high-affinity recombinant ... [An article from: Analytica Chimica Acta]
S.M. Varnum , M.G. Warner , B. Dockendorff , and Anheier
Manufacturer: Elsevier
ProductGroup: Book
Binding: Digital

Elsevier | By Publisher | e-Docs | Formats | Books
ASIN: B000P6NSNK

Book Description

This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Two immunoassay platforms were developed for either the sensitive or rapid detection of botulinum neurotoxin A (BoNT/A), using high-affinity recombinant monoclonal antibodies against the receptor binding domain of the heavy chain of BoNT/A. These antibodies also bind the same epitopes of the receptor binding domain present on a nontoxic recombinant heavy chain fragment used for assay development and testing in the current study. An enzyme-linked immunosorbent assay (ELISA) microarray using tyramide amplification for localized labeling was developed for the specific and sensitive detection of BoNT. This assay has the sensitivity to detect BoNT in buffer and blood plasma samples down to 14fM (1.4pgmL^-^1). Three capture antibodies and one antibody combination were compared in the development of this assay. Using a selected pair from the same set of recombinant monoclonal antibodies, a renewable surface microcolumn sensor was developed for the rapid detection of BoNT/A in an automated fluidic system. The ELISA microarray assay, because of its sensitivity, offers a screening test with detection limits comparable to the mouse bioassay, with results available in hours instead of days. The renewable surface assay is less sensitive but much faster, providing results in less than 10min.

Customer Reviews:

A good starting point.......2001-08-25

Zencey's short glimpses at the struggles which many of us face as we try to fit what we know, naturally, to be right, with the struggles of modern existence come together to form a foundation for a deeper exploration into modern ecology and environmental protection and exploration. I recommend the book as a starting point, and introduction, for anyone who is interested in figuring out how humans can make it for another few thousand years. This book does not provide many answers, but it asks many of the right questions.

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